{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have demonstrated that the long non‐coding RNA ENTPD3‐AS1 plays a multifaceted role in cancer pathogenesis. In renal cell carcinoma (RCC), a functional SNP (rs67311347) leads to the creation of a novel binding motif for the transcription factor ZNF8, which in turn upregulates ENTPD3‐AS1 expression via enhancer activity. Despite its overall downregulation in RCC tissues, increased ENTPD3‐AS1 levels are associated with improved overall and progression‐free survival. Functionally, ENTPD3‐AS1 exerts tumor‐suppressive effects by interacting with miR‐155-5p to activate the expression of the tumor suppressor HIF-1α; notably, the anti-proliferative effects of ENTPD3‐AS1 in RCC cell lines are abrogated upon HIF-1α knockdown."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Moreover, through comprehensive ceRNA network analyses, ENTPD3‐AS1 has been identified as a potential prognostic biomarker and therapeutic target in clear cell kidney carcinoma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition to its role in RCC, genetic studies have implicated ENTPD3‐AS1 as a rare variant associated with prostate cancer susceptibility in a Korean population."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Although a separate study examining genomic regulatory regions and nearby long intergenic non-coding RNAs (lincRNAs) did not directly elaborate on ENTPD3‐AS1"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", the convergence of data from these analyses indicates that ENTPD3‐AS1 may function as an important regulator in tumorigenesis by modulating miRNA-mediated signaling pathways.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jiangyi Wang, Yun Zou, Bowen Du, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SNP-mediated lncRNA-ENTPD3-AS1 upregulation suppresses renal cell carcinoma via miR-155/HIF-1α signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-021-03958-4"}], "href": "https://doi.org/10.1038/s41419-021-03958-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34218253"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34218253"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hehuan Zhu, Jun Lu, Hu Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional Long Noncoding RNAs (lncRNAs) in Clear Cell Kidney Carcinoma Revealed by Reconstruction and Comprehensive Analysis of the lncRNA-miRNA-mRNA Regulatory Network."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Sci Monit (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.12659/MSM.910773"}], "href": "https://doi.org/10.12659/MSM.910773"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30444862"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30444862"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jong Jin Oh, Manu Shivakumar, Jason Miller, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An exome-wide rare variant analysis of Korean men identifies three novel genes predisposing to prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-019-53445-2"}], "href": "https://doi.org/10.1038/s41598-019-53445-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31748686"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31748686"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Megan Leask, Amy Dowdle, Hamish Salvesen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional Urate-Associated Genetic Variants Influence Expression of lincRNAs "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "LINC01229"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " and "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "MAFTRR"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Genet (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fgene.2018.00733"}], "href": "https://doi.org/10.3389/fgene.2018.00733"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30719032"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30719032"}]}]}]}