{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n EP300-AS1 appears to represent one of the estrogen receptor agitation‐related long non‐coding RNAs identified as part of a comprehensive investigation into lncRNA regulation of estrogen receptor signaling in breast cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " The study demonstrated that several ERAR lncRNAs, including EP300-AS1, are co-expressed with genes involved in key cellular processes such as mitosis, the DNA damage response, and DNA repair. Moreover, a subset of these lncRNAs was significantly associated with endocrine resistance-free survival, distant metastasis-free survival, and disease-free survival, suggesting that EP300-AS1 may have prognostic relevance in the context of breast cancer progression and treatment response. Together, these findings imply that EP300-AS1 could serve as a valuable biomarker to not only enhance our understanding of estrogen receptor–mediated tumor biology but also to guide therapeutic decision-making in hormone-responsive breast cancer.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Liangcai Wu, Qianqian Xu, Haohai Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A new avenue for obtaining insight into the functional characteristics of long noncoding RNAs associated with estrogen receptor signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep31716"}], "href": "https://doi.org/10.1038/srep31716"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27539025"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27539025"}]}]}]}