{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n EPB41L4A-AS2 is a long noncoding RNA that functions predominantly as a tumor suppressor across multiple cancer types. In hepatocellular carcinoma, EPB41L4A-AS2 is significantly downregulated, and its overexpression impedes cell proliferation, migration, and invasion by acting as a molecular sponge for miR‐301a-5p, thereby de‐repressing the expression of the tumor suppressor gene FOXL1."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In breast, renal, and lung cancers, elevated EPB41L4A-AS2 levels associate with favorable prognosis and reduced tumor cell proliferation, further underscoring its inhibitory role in solid tumor formation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, in ovarian cancer, EPB41L4A-AS2 suppresses cell proliferation, migration, and invasion by binding to miR-103a and promoting RUNX1T1 expression, highlighting its potential as a therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In head and neck squamous cell carcinoma, EPB41L4A-AS2 is downregulated by transforming growth factor-β and its restoration hampers epithelial-to-mesenchymal transition, thus reducing metastatic behavior."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Consistent with these findings, in breast cancer, EPB41L4A-AS2 is epigenetically suppressed and its overexpression not only inhibits cell proliferation and invasion but also upregulates tumor suppressor gene expression, correlating with improved patient outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Similarly, in non-small cell lung cancer, low levels of EPB41L4A-AS2 are linked to poor survival, while forced expression induces cell cycle arrest, increased apoptosis, and diminished invasive capabilities."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Finally, its potential as a biomarker is further supported by studies in docetaxel-resistant breast cancer cell lines, where EPB41L4A-AS2 expression is indicative of chemosensitivity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yu-Gang Wang, Tao Wang, Min Shi, et al. 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