{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nEPCIP, identified as CU062 (Q9NYP8), is a small, secreted glycoprotein that lacks a transmembrane domain and functions as a candidate component of the polycystin complex (PCC). The protein oligomerizes with itself and interacts directly with polycystin-1 (PC1) and polycystin-2 (PC2), key players in autosomal dominant polycystic kidney disease (ADPKD). In nonconfluent cells, EPCIP co-localizes with PC1 and PC2 near focal adhesions, retraction fibers, and migrasomes—extracellular vesicles implicated in cell migration and turnover."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "In conditions of cellular stress, such as mitochondrial decoupling and contact inhibition, EPCIP is observed within novel PC1/CU062 ring-like structures that appear to entrap swollen, potentially senescent mitochondria. Additionally, in confluent cells, EPCIP associates with extracellular vesicles adherent to primary cilia. This pattern of localization suggests that EPCIP might play an essential role in monitoring mitochondrial integrity and in orchestrating the removal of damaged mitochondria via extracellular vesicle shedding—a process that may be particularly relevant to the pathogenesis of ADPKD."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Wendy A Lea, Thomas Winklhofer, Lesya Zelenchuk, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polycystin-1 Interacting Protein-1 (CU062) Interacts with the Ectodomain of Polycystin-1 (PC1)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cells (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/cells12172166"}], "href": "https://doi.org/10.3390/cells12172166"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37681898"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37681898"}]}]}]}