{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent integrative genetic analyses have highlighted the involvement of noncoding genomic regions in Alzheimer’s disease (AD) pathogenesis. In one study, summary data-based Mendelian randomization was applied to combine genome‐wide association study (GWAS) and expression quantitative trait loci (eQTL) data, which identified several single nucleotide polymorphisms (SNPs) that not only contribute to AD risk but also modulate the expression of nearby genes. Among the validated risk-associated SNPs, one (rs679515) was found to influence the expression of EPHA1-AS1, a long noncoding RNA. Although the precise biological function of EPHA1-AS1 remains to be fully elucidated, its altered expression in the context of AD risk suggests that it may play a regulatory role in gene expression networks that are pertinent to the disease’s pathogenesis (1)."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jin Zhu, Xia Liu, Hongtao Yin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Convergent lines of evidence support BIN1 as a risk gene of Alzheimer's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Genomics (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s40246-021-00307-6"}], "href": "https://doi.org/10.1186/s40246-021-00307-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33516273"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33516273"}]}]}]}