{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n EPHA5‐AS1 appears to be one of several long noncoding RNAs whose dysregulation is linked to disease‐associated cellular processes. In one study focused on liver fibrosis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", analysis of human hepatic stellate cell myofibroblasts revealed that many lncRNAs—including those such as EPHA5‐AS1—are induced by transforming growth factor–β signaling and are enriched at super‐enhancers. Such lncRNAs show a restricted expression pattern in hepatic stellate cells compared with a broad panel of human tissues and are co‐expressed with key extracellular matrix genes; this suggests they may play roles in orchestrating extracellular matrix modulation and fibrotic scar formation during liver disease progression. In a separate investigation into thyroid cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ", numerous lncRNAs were identified as aberrantly expressed and some were associated with copy number variations as well as poor clinical outcomes. Although EPHA5‐AS1 is not highlighted individually by functional experiments in this context, its inclusion among differentially regulated lncRNAs implies that it may also contribute to thyroid tumorigenesis—potentially influencing cell proliferation, invasion, and survival. \n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Overall, the available findings support a role for EPHA5‐AS1 as a regulatory RNA that, depending on cellular context, may contribute to extracellular matrix remodeling in fibrotic liver disease as well as to oncogenic processes in thyroid cancer.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Chan Zhou, Samuel R York, Jennifer Y Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNAs expressed in human hepatic stellate cells form networks with extracellular matrix proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genome Med (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13073-016-0285-0"}], "href": "https://doi.org/10.1186/s13073-016-0285-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27007663"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27007663"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Wei Lu, Yongcan Xu, Jiewei Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of differential expressed lncRNAs in human thyroid cancer by a genome-wide analyses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cam4.1627"}], "href": "https://doi.org/10.1002/cam4.1627"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29923329"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29923329"}]}]}]}