| HGNC Family | WAP four-disulfide core domain containing (WFDC) |
| Name | epididymal peptidase inhibitor |
| Description | This gene encodes an epididymal protease inhibitor, which contains both kunitz-type and WAP-type four-disulfide core (WFDC) protease inhibitor consensus sequences. Most WFDC genes are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene is a member of the WFDC gene family and belongs to the telomeric cluster. The protein can inhibit human sperm motility and exhibits antimicrobial activity against E. coli, and polymorphisms in this gene are associated with male infertility. Read-through transcription also exists between this gene and the downstream WFDC6 (WAP four-disulfide core domain 6) gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Epididymal protease inhibitor (EPPIN) is a multifunctional protein expressed primarily in the testis and epididymis that plays a critical role in male fertility. On the sperm surface, EPPIN binds to seminal plasma proteins—most notably semenogelin‐1—to form a complex that modulates sperm motility by transiently inhibiting progressive movement, an effect that can be reversed by proteolytic digestion during semen liquefaction (1,2,3,17). In addition to its role in regulating motility, EPPIN exhibits antibacterial properties; it disrupts both the outer and inner membranes of bacteria in a manner dependent on intact disulfide bonds and its dual inhibitory domains, suggesting that antimicrobial defense in the male reproductive tract is an additional physiological function (1,4). Moreover, EPPIN may influence intracellular signaling in spermatozoa; antibody‐mediated blockade of EPPIN has been shown to reduce intracellular calcium influx and inhibit the acrosome reaction, thereby demonstrating its regulatory role in fertilization (5). Genetic and immunization studies further support the significance of EPPIN as a key target for non‐hormonal contraception, with specific gene variants correlating with altered semen quality and vaccination against EPPIN resulting in reduced fertility in animal models (6,8,12,13,14,15,16). Collectively, these findings underscore the dual protective and modulatory functions of EPPIN in sperm maturation and function, as well as its promise as a candidate antigen for the development of male contraceptive strategies."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "b", "children": [{"type": "t", "text": "Citations:"}]}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "17"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Suresh Yenugu, Richard T Richardson, Perumal Sivashanmugam, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Antimicrobial activity of human EPPIN, an androgen-regulated, sperm-bound protein with a whey acidic protein motif."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Reprod (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1095/biolreprod.104.031567"}], "href": "https://doi.org/10.1095/biolreprod.104.031567"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15229136"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15229136"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zengjun Wang, E E Widgren, P Sivashanmugam, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of eppin with semenogelin on human spermatozoa."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Reprod (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1095/biolreprod.104.036483"}], "href": "https://doi.org/10.1095/biolreprod.104.036483"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15590901"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15590901"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Anurag Mitra, Richard T Richardson, Michael G O'Rand "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of recombinant human semenogelin as an inhibitor of human sperm motility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Reprod (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1095/biolreprod.109.081331"}], "href": "https://doi.org/10.1095/biolreprod.109.081331"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19889947"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19889947"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Maelíosa T C McCrudden, Tim R Dafforn, David F Houston, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional domains of the human epididymal protease inhibitor, eppin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS J (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1742-4658.2008.06333.x"}], "href": "https://doi.org/10.1111/j.1742-4658.2008.06333.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18331357"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18331357"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jie Zhang, Xinliang Ding, Zenghui Bian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The effect of anti-eppin antibodies on ionophore A23187-induced calcium influx and acrosome reaction of human spermatozoa."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Reprod (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/humrep/dep356"}], "href": "https://doi.org/10.1093/humrep/dep356"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19801569"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19801569"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Erick J R Silva, Katherine G Hamil, Richard T Richardson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of EPPIN's semenogelin I binding site: a contraceptive drug target."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Reprod (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1095/biolreprod.112.101832"}], "href": "https://doi.org/10.1095/biolreprod.112.101832"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22699487"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22699487"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Noemia A P Mariani, Aline C Camara, Alan Andrew S Silva, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epididymal protease inhibitor (EPPIN) is a protein hub for seminal vesicle-secreted protein SVS2 binding in mouse spermatozoa."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Endocrinol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mce.2020.110754"}], "href": "https://doi.org/10.1016/j.mce.2020.110754"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32044375"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32044375"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Xinliang Ding, Jie Zhang, Zenghui Bian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Variants in the Eppin gene show association with semen quality in Han-Chinese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Reprod Biomed Online (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.rbmo.2009.10.025"}], "href": "https://doi.org/10.1016/j.rbmo.2009.10.025"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20158997"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20158997"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Yan Long, Aihua Gu, Hua Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Distribution of Eppin in mouse and human testis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2010.403"}], "href": "https://doi.org/10.3892/mmr.2010.403"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21461566"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21461566"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Erick J R Silva, Marília T C C Patrão, James K Tsuruta, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epididymal protease inhibitor (EPPIN) is differentially expressed in the male rat reproductive tract and immunolocalized in maturing spermatozoa."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Reprod Dev (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mrd.22119"}], "href": "https://doi.org/10.1002/mrd.22119"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23070980"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23070980"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Adam Clauss, Hans Lilja, Ake Lundwall "}, {"type": "b", "children": [{"type": "t", "text": "A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20020869"}], "href": "https://doi.org/10.1042/BJ20020869"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12206714"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12206714"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "A H Bandivdekar "}, {"type": "b", "children": [{"type": "t", "text": "Development of antifertility vaccine using sperm specific proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Indian J Med Res (2014)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25673547"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25673547"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Zhengqiong Chen, Zigang Shen, Jintao Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nasal immunization using a mimovirus vaccine based on the Eppin B-cell epitope induced suppressed fertility in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Vaccin Immunother (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/hv.29200"}], "href": "https://doi.org/10.4161/hv.29200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25424926"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25424926"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Xinliang Ding, Jie Zhang "}, {"type": "b", "children": [{"type": "t", "text": "[The association study between Eppin gene polymorphisms and idiopathic male infertility]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhonghua Yu Fang Yi Xue Za Zhi (2014)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25619219"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25619219"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Ping Yan, Wei He, Yuzhang Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Enhanced Suppression of Fertility Can be Achieved by Priming with FSHR and Eppin and Further Boosting with Their B-cell Epitope Peptides."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Reprod Immunol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/aji.12381"}], "href": "https://doi.org/10.1111/aji.12381"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25864521"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25864521"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Zygmunt Zdrojewicz, Radosław Konieczny, Paulina Papier, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Brdt Bromodomains Inhibitors and Other Modern Means of Male Contraception."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Adv Clin Exp Med (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.17219/acem/33827"}], "href": "https://doi.org/10.17219/acem/33827"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26469117"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26469117"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Changyu Shan, Hongwei Li, Yuping Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Binding interactions of epididymal protease inhibitor and semenogelin-1: a homology modeling, docking and molecular dynamics simulation study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PeerJ (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7717/peerj.7329"}], "href": "https://doi.org/10.7717/peerj.7329"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31404433"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31404433"}]}]}]}
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| Synonyms | CT71, WAP7, WFDC7, CT72, DJ461P17.2, SPINLW1 |
| Proteins | EPPI_HUMAN |
| NCBI Gene ID | 57119 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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EPPIN has 2,876 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 74 datasets.
Click the + buttons to view associations for EPPIN from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of EPPIN gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of EPPIN gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of EPPIN gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of EPPIN gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
| BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of EPPIN gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
| BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of EPPIN gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
| Carcinogenome Chemical Perturbation Carcinogenicity Signatures | small molecule perturbations changing expression of EPPIN gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of EPPIN gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of EPPIN gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of EPPIN gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of EPPIN gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of EPPIN gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of EPPIN gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing EPPIN protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing EPPIN protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with EPPIN protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with EPPIN protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of EPPIN gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with EPPIN gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| CTD Gene-Disease Associations | diseases associated with EPPIN gene/protein from the curated CTD Gene-Disease Associations dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by EPPIN gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with EPPIN gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with EPPIN gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Phenotype Associations | phenotypes associated with EPPIN gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at EPPIN gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of EPPIN gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of EPPIN gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing EPPIN from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
| GAD Gene-Disease Associations | diseases associated with EPPIN gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
| GAD High Level Gene-Disease Associations | diseases associated with EPPIN gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset. | |
| GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of EPPIN gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with EPPIN gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing EPPIN from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of EPPIN gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of EPPIN gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of EPPIN gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of EPPIN gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of EPPIN gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving EPPIN gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving EPPIN gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2023 | cellular components containing EPPIN protein from the curated GO Cellular Component Annotations 2023 dataset. | |
| GO Cellular Component Annotations 2025 | cellular components containing EPPIN protein from the curated GO Cellular Component Annotations 2025 dataset. | |
| GTEx eQTL 2025 | SNPs regulating expression of EPPIN gene from the GTEx eQTL 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of EPPIN gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of EPPIN gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| HPA Tissue Gene Expression Profiles | tissues with high or low expression of EPPIN gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
| HuGE Navigator Gene-Phenotype Associations | phenotypes associated with EPPIN gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of EPPIN gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of EPPIN gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of EPPIN gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of EPPIN gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of EPPIN gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
| LOCATE Curated Protein Localization Annotations | cellular components containing EPPIN protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain EPPIN protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MiRTarBase microRNA Targets | microRNAs targeting EPPIN gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of EPPIN gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of EPPIN gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of EPPIN gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PFOCR Pathway Figure Associations 2024 | pathways involving EPPIN protein from the Wikipathways PFOCR 2024 dataset. | |
| Reactome Pathways 2024 | pathways involving EPPIN protein from the Reactome Pathways 2024 dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at EPPIN gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of EPPIN gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of EPPIN gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of EPPIN gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| Tabula Sapiens Gene-Cell Associations | cell types with high or low expression of EPPIN gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset. | |
| TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of EPPIN gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of EPPIN gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of EPPIN gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of EPPIN protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of EPPIN protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of EPPIN protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with EPPIN protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with EPPIN protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
| WikiPathways Pathways 2024 | pathways involving EPPIN protein from the WikiPathways Pathways 2024 dataset. | |
