{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n ERC2‐IT1 is an immune‐related long non‐coding RNA that has been identified as a component of a prognostic signature in neuroblastoma. In the context of this study, ERC2‐IT1, along with several other immune‐related lncRNAs, was used to stratify patients into risk groups based on overall and event/progression‐free survival. Specifically, higher expression levels of ERC2‐IT1, as part of a composite risk score, were associated with a poorer prognosis. Its expression correlates negatively with populations of activated dendritic cells and CD8⁺ T cells, while showing a positive correlation with Th2 cells; these associations suggest that ERC2‐IT1 may contribute to establishing an immunosuppressive tumor microenvironment that favors neuroblastoma progression. Functional enrichment analyses further indicate that lncRNAs within this prognostic network are implicated in cancer‐ and immune‐related pathways, underscoring a potential role for ERC2‐IT1 in modulating tumor–immune interactions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiaodan Zhong, Ying Tao, Jian Chang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prognostic Signature of Immune Genes and Immune-Related LncRNAs in Neuroblastoma: A Study Based on GEO and TARGET Datasets."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fonc.2021.631546"}], "href": "https://doi.org/10.3389/fonc.2021.631546"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33767996"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33767996"}]}]}]}