{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations into secreted glycoproteins have revealed that factors such as galectin‐3 binding protein (LGALS3BP) regulate immune cell activity and tumor progression. In malignant settings, LGALS3BP acts as a sialic acid–dependent ligand for immunomodulatory Siglecs, thereby dampening neutrophil activation and facilitating tumor immune evasion. Similarly, its involvement in thrombosis relates to its colocalization with inflammatory mediators, suggesting that secreted proteins can influence both cellular adhesion and cytokine‐mediated signaling in cancer and thrombotic pathologies."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn parallel, studies focusing on cyclophilin C‐associated protein (CyCAP) have demonstrated its essential role in extracellular matrix regulation and tissue repair. Loss or altered regulation of CyCAP disrupts extracellular matrix integrity by changing fibronectin and collagen fragmentation and by deregulating matrix metalloproteinases. These findings also underscore the importance of endoplasmic reticulum–associated post‐translational modifications in maintaining normal tissue homeostasis, with implications for processes such as colonic mucosal hyperplasia and wound healing."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional work exploring non‐coding RNA regulation in cancer and other disease models has begun to elucidate how regulatory RNAs can modulate key signaling pathways. For instance, long non‐coding RNAs have been shown to suppress oncogenic proteins via mechanisms such as enhanced ubiquitination, while secreted adipokines and CNS proteins contribute to inflammatory responses in both brown adipose tissue and microglia. Although none of these studies directly address ERCC6L2‐AS1, integration of these diverse findings raises the possibility that ERCC6L2‐AS1—like other regulatory non‐coding RNAs—may function to coordinate the expression, modification, and secretion of proteins involved in immune signaling, cellular adhesion, and stress responses under oncogenic and inflammatory conditions."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Heinz Läubli, Frederico Alisson-Silva, Michal A Stanczak, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Cyclophilin C-associated protein (CyCAP) knock-out mice spontaneously develop colonic mucosal hyperplasia and exaggerated tumorigenesis after treatment with carcinogen azoxymethane."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2407-9-251"}], "href": "https://doi.org/10.1186/1471-2407-9-251"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19627619"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19627619"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Wuyi Kong, Bryan W Lin, Shaowei Li, et al. 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