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Their activity also influences tumor progression via termination of growth factor signaling in epithelial cells, while in the nervous system, inappropriate proteolytic processing can precipitate protein aggregation associated with neurodegenerative conditions. Collectively, these insights underscore that the diverse catalytic functions of ETDC proteases integrate regulation of immune responses, cellular differentiation and survival, and extracellular matrix dynamics—all of which are critical to both normal physiology and disease pathogenesis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "31", "end_ref": "45"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Kartik Chandran, Nancy J Sullivan, Ute Felbor, et al. 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