ETFRF1 Gene

Name electron transfer flavoprotein regulatory factor 1
Description Involved in respiratory electron transport chain. Located in mitochondrion. [provided by Alliance of Genome Resources, Mar 2025]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n ETFRF1, also known as LYRM5, is emerging as a multifunctional mitochondrial protein that contributes to both energy homeostasis and disease‐associated processes. As a member of the LYR motif protein family, ETFRF1 appears to play a role in the structural and functional organization of oxidative phosphorylation complexes – for example, by helping anchor key accessory proteins (such as acyl–carrier proteins) to complex I in mitochondria, thereby supporting proper electron transport and mitochondrial bioenergetics."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Moreover, recent evidence in the cancer field has linked upregulation of ETFRF1/LYRM5 to the promotion of angiogenesis in non–small cell lung carcinoma. In this setting, a circular RNA (circPTN) acts as a competing endogenous RNA by sponging microRNA‐595, which leads to increased expression of ETFRF1/LYRM5 and in turn facilitates enhanced angiogenesis that correlates with poorer overall survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Collectively, these observations suggest that ETFRF1/LYRM5 functions as a regulatory factor at the crossroads of mitochondrial respiratory complex assembly and tumor angiogenesis, making it an attractive candidate for further mechanistic investigations and potential therapeutic targeting.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Heike Angerer "}, {"type": "b", "children": [{"type": "t", "text": "Eukaryotic LYR Proteins Interact with Mitochondrial Protein Complexes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biology (Basel) (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/biology4010133"}], "href": "https://doi.org/10.3390/biology4010133"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25686363"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25686363"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Shengcong Guo, Zejun Mao, Guodong Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CircPTN promotes angiogenesis via the MiR-595/LYRM5 signaling pathway in non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transl Cancer Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.21037/tcr-22-195"}], "href": "https://doi.org/10.21037/tcr-22-195"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35402183"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35402183"}]}]}]}
NCBI Gene ID 144363
API
Download Associations
Predicted Functions View ETFRF1's ARCHS4 Predicted Functions.
Co-expressed Genes View ETFRF1's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View ETFRF1's ARCHS4 Predicted Functions.

Functional Associations

ETFRF1 has 1,178 functional associations with biological entities spanning 6 categories (functional term, phrase or reference, disease, phenotype or trait, chemical, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 28 datasets.

Click the + buttons to view associations for ETFRF1 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles tissue samples with high or low expression of ETFRF1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
CCLE Cell Line Proteomics Cell lines associated with ETFRF1 protein from the CCLE Cell Line Proteomics dataset.
CellMarker Gene-Cell Type Associations cell types associated with ETFRF1 gene from the CellMarker Gene-Cell Type Associations dataset.
ChEA Transcription Factor Targets 2022 transcription factors binding the promoter of ETFRF1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
CM4AI KOLF21J CRISPRi Gene Perturbation Atlas gene perturbations changing expression of ETFRF1 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
COMPARTMENTS Curated Protein Localization Evidence Scores 2025 cellular components containing ETFRF1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 cellular components containing ETFRF1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 cellular components co-occuring with ETFRF1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
DepMap CRISPR Gene Dependency cell lines with fitness changed by ETFRF1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 diseases co-occuring with ETFRF1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
GO Biological Process Annotations 2023 biological processes involving ETFRF1 gene from the curated GO Biological Process Annotations 2023 dataset.
GO Biological Process Annotations 2025 biological processes involving ETFRF1 gene from the curated GO Biological Process Annotations2025 dataset.
GTEx eQTL 2025 SNPs regulating expression of ETFRF1 gene from the GTEx eQTL 2025 dataset.
GTEx Tissue Gene Expression Profiles 2023 tissues with high or low expression of ETFRF1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
GTEx Tissue-Specific Aging Signatures tissue samples with high or low expression of ETFRF1 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset.
JASPAR Predicted Human Transcription Factor Targets 2025 transcription factors regulating expression of ETFRF1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.
JASPAR Predicted Mouse Transcription Factor Targets 2025 transcription factors regulating expression of ETFRF1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset.
MoTrPAC Rat Endurance Exercise Training tissue samples with high or low expression of ETFRF1 gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset.
NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles drug perturbations changing expression of ETFRF1 gene from the NIBR DRUG-seq U2OS MoA Box dataset.
Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures gene perturbations changing expression of ETFRF1 gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset.
Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures gene perturbations changing expression of ETFRF1 gene from the Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures dataset.
Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures gene perturbations changing expression of ETFRF1 gene from the Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures dataset.
Rummagene Transcription Factor Associations 2026 transcription factors regulating expression of ETFRF1 gene from the Rummagene Transcription Factor Associations 2026 dataset.
RummaGEO Drug Perturbation Signatures drug perturbations changing expression of ETFRF1 gene from the RummaGEO Drug Perturbation Signatures dataset.
RummaGEO Gene Perturbation Signatures gene perturbations changing expression of ETFRF1 gene from the RummaGEO Gene Perturbation Signatures dataset.
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 tissues with high expression of ETFRF1 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 tissues with high expression of ETFRF1 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 tissues co-occuring with ETFRF1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.