EXTL3 Gene

HGNC Family	Glycosyltransferases
Name	exostosin-like glycosyltransferase 3
Description	This gene encodes a single-pass membrane protein which functions as a glycosyltransferase. The encoded protein catalyzes the transfer of N-acetylglucosamine to glycosaminoglycan chains. This reaction is important in heparin and heparan sulfate synthesis. Alternative splicing results in the multiple transcript variants. [provided by RefSeq, Nov 2012]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n EXTL3 is a multifunctional protein that plays a dual role in human biology. As a glycosyltransferase, EXTL3 is critical for the biosynthesis of heparan sulfate (HS) proteoglycans by initiating and elongating HS chains, a process that is essential for normal skeletal, neural, and immunological development. This function is underscored by clinical findings in patients with mutations in EXTL3, who exhibit complex neuro‐immuno‐skeletal dysplasia and spondyloepimetaphyseal dysplasia with immune deficiency, indicating that improper HS assembly leads to significant developmental defects."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "7"}]}, {"type": "t", "text": " Moreover, EXTL3 can regulate the activity of other enzymes such as NDST‑1 to affect the sulfation pattern of HS, thereby fine‐tuning the structural and functional properties of the HS chains."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition to its biosynthetic role, EXTL3 functions as a cell surface receptor for several regenerating (Reg) family proteins. Binding of ligands such as REG3A, REG1α, REG3B, and the human proislet peptide (HIP) to EXTL3 initiates intracellular signaling cascades—including the PI3K/AKT and RAS‑RAF‑MEK‑ERK pathways—that promote keratinocyte proliferation, neurite outgrowth, islet neogenesis, and even acinar‐to‐ductal metaplasia in the pancreas."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "13"}]}, {"type": "t", "text": " These receptor‐mediated effects are central not only to processes of tissue regeneration and repair but also to the pathogenesis of several diseases.\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Aberrant expression, epigenetic silencing, or structural defects of EXTL3 have been linked to pathological conditions such as gastrointestinal cancers and endometriosis, reflecting its broader role in cell proliferation, differentiation, and apoptosis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "14", "end_ref": "16"}]}, {"type": "t", "text": " Structural studies further indicate that proper N‑glycosylation of EXTL3 is necessary for its stability and function, emphasizing a tightly regulated control of its biochemistry."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In summary, EXTL3 is pivotal both as an enzyme catalyzing HS chain biosynthesis and as a receptor mediating extracellular growth signals. This dual functionality underlies its essential roles in development, tissue regeneration, and disease pathogenesis.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Marta Busse, Almir Feta, Jenny Presto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Contribution of EXT1, EXT2, and EXTL3 to heparan sulfate chain elongation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M703560200"}], "href": "https://doi.org/10.1074/jbc.M703560200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17761672"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17761672"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Stefano Volpi, Yasuhiro Yamazaki, Patrick M Brauer, et al. "}, {"type": "b", "children": [{"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "EXTL3"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " mutations cause skeletal dysplasia, immune deficiency, and developmental delay."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20161525"}], "href": "https://doi.org/10.1084/jem.20161525"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28148688"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28148688"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Machteld M Oud, Paul Tuijnenburg, Maja Hempel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in EXTL3 Cause Neuro-immuno-skeletal Dysplasia Syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2017.01.013"}], "href": "https://doi.org/10.1016/j.ajhg.2017.01.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28132690"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28132690"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Long Guo, Nursel H Elcioglu, Shuji Mizumoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of biallelic EXTL3 mutations in a novel type of spondylo-epi-metaphyseal dysplasia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hum Genet (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/jhg.2017.38"}], "href": "https://doi.org/10.1038/jhg.2017.38"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28331220"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28331220"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Noura M S Osman, Y Kagohashi, J Udagawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Alpha1,4-N-acetylglucosaminyltransferase encoding gene EXTL3 expression pattern in mouse adult and developing tissues with special attention to the pancreas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Anat Embryol (Berl) (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00429-003-0348-z"}], "href": "https://doi.org/10.1007/s00429-003-0348-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14618397"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14618397"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Noura M S Osman, Hiroyuki Naora, Hiroki Otani "}, {"type": "b", "children": [{"type": "t", "text": "Glycosyltransferase encoding gene EXTL3 is differentially expressed in the developing and adult mouse cerebral cortex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain Res Dev Brain Res (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.devbrainres.2004.04.008"}], "href": "https://doi.org/10.1016/j.devbrainres.2004.04.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15246697"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15246697"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Akçahan Akalın, Ekim Z Taskiran, Pelin Özlem Şimşek-Kiper, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Spondyloepimetaphyseal dysplasia EXTL3-deficient type: Long-term follow-up and review of the literature."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet A (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.a.62378"}], "href": "https://doi.org/10.1002/ajmg.a.62378"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34089299"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34089299"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Satomi Nadanaka, Eko Purunomo, Naoko Takeda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Heparan sulfate containing unsubstituted glucosamine residues: biosynthesis and heparanase-inhibitory activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M113.545343"}], "href": "https://doi.org/10.1074/jbc.M113.545343"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24753252"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24753252"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Yuping Lai, Dongqing Li, Changwei Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The antimicrobial protein REG3A regulates keratinocyte proliferation and differentiation after skin injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunity (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.immuni.2012.04.010"}], "href": "https://doi.org/10.1016/j.immuni.2012.04.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22727489"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22727489"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Isabelle Acquatella-Tran Van Ba, Stéphane Marchal, Florence François, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regenerating islet-derived 1α (Reg-1α) protein is new neuronal secreted factor that stimulates neurite outgrowth via exostosin Tumor-like 3 (EXTL3) receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.260349"}], "href": "https://doi.org/10.1074/jbc.M111.260349"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22158612"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22158612"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Claresa S Levetan, Loraine V Upham, Shaoping Deng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Discovery of a human peptide sequence signaling islet neogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocr Pract (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4158/EP.14.9.1075"}], "href": "https://doi.org/10.4158/EP.14.9.1075"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19158046"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19158046"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Huairong Zhang, Andrea Liliam Gomez Corredor, Julia Messina-Pacheco, et al. "}, {"type": "b", "children": [{"type": "t", "text": "REG3A/REG3B promotes acinar to ductal metaplasia through binding to EXTL3 and activating the RAS-RAF-MEK-ERK signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Commun Biol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s42003-021-02193-z"}], "href": "https://doi.org/10.1038/s42003-021-02193-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34099862"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34099862"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Erika Sugisawa, Takeshi Kondo, Yutaro Kumagai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nociceptor-derived Reg3γ prevents endotoxic death by targeting kynurenine pathway in microglia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2022.110462"}], "href": "https://doi.org/10.1016/j.celrep.2022.110462"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35263589"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35263589"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "T Karibe, H Fukui, A Sekikawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "EXTL3 promoter methylation down-regulates EXTL3 and heparan sulphate expression in mucinous colorectal cancers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Pathol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/path.2377"}], "href": "https://doi.org/10.1002/path.2377"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18543267"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18543267"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Ken Hara, Hirokazu Fukui, Chao Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effect of REG Iα protein on angiogenesis in gastric cancer tissues."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2015.3878"}], "href": "https://doi.org/10.3892/or.2015.3878"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25813126"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25813126"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Alar Aints, Signe Mölder, Andres Salumets "}, {"type": "b", "children": [{"type": "t", "text": "EXTL3-interacting endometriosis-specific serum factors induce colony formation of endometrial stromal cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-019-48840-8"}], "href": "https://doi.org/10.1038/s41598-019-48840-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31467315"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31467315"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Wael Awad, Sven Kjellström, Gabriel Svensson Birkedal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural and Biophysical Characterization of Human EXTL3: Domain Organization, Glycosylation, and Solution Structure."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/acs.biochem.7b00557"}], "href": "https://doi.org/10.1021/acs.biochem.7b00557"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29346724"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29346724"}]}]}]}
Synonyms	RPR, REGR, EXTL1L, BOTV, ISDNA, EXTR1
Proteins	EXTL3_HUMAN
NCBI Gene ID	2137
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

EXTL3 has 6,690 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 120 datasets.

Click the + buttons to view associations for EXTL3 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

EXTL3 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of EXTL3 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of EXTL3 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of EXTL3 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of EXTL3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of EXTL3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of EXTL3 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of EXTL3 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of EXTL3 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of EXTL3 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of EXTL3 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of EXTL3 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of EXTL3 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with EXTL3 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with EXTL3 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of EXTL3 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of EXTL3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of EXTL3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with EXTL3 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of EXTL3 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing EXTL3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing EXTL3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with EXTL3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with EXTL3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of EXTL3 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with EXTL3 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with EXTL3 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of EXTL3 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by EXTL3 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with EXTL3 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with EXTL3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with EXTL3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with EXTL3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with EXTL3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at EXTL3 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of EXTL3 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of EXTL3 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing EXTL3 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of EXTL3 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with EXTL3 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing EXTL3 from the GeneSigDB Published Gene Signatures dataset.