{"type": "root", "children": [{"type": "t", "text": "<head>\n <meta charset=\"UTF-8\">\n <title>Summary of EZR-AS1 Function</title>\n </head>\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Our consolidated analysis of recent studies reveals that the long non‐coding RNA (lncRNA) EZR‑AS1 functions as an oncogenic regulator across several cancer types by promoting cell migration, invasion, proliferation, and epithelial‐mesenchymal transition (EMT). In esophageal squamous cell carcinoma, EZR‑AS1 is co‑expressed with and up‑regulates its sense gene EZR by forming a complex with RNA polymerase II and recruiting the histone methyltransferase SMYD3, thereby increasing local H3K4 trimethylation and driving enhanced cellular mobility and invasiveness."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In cutaneous squamous cell carcinoma, EZR‑AS1 overexpression contributes to tumor progression by modulating focal adhesion kinase (FAK) levels and activating the PI3K/AKT signaling pathway, which promotes cell survival and metastatic potential."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Similarly, in breast cancer, elevated EZR‑AS1 expression correlates with poor clinical outcomes through its interaction with β‑catenin, preventing β‑catenin degradation and thereby activating the Wnt/β‑catenin pathway to enhance proliferation and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, in colorectal cancer, silencing EZR‑AS1 has been shown to inhibit cell proliferation, migration, and EMT by disrupting TGF‑β signaling, further underscoring its role in tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Collectively, these findings establish EZR‑AS1 as a multifaceted oncogenic lncRNA that modulates key transcriptional and signaling networks to facilitate tumor development and metastasis.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiao-Dan Zhang, Guo-Wei Huang, Ying-Hua Xie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The interaction of lncRNA EZR-AS1 with SMYD3 maintains overexpression of EZR in ESCC cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkx1259"}], "href": "https://doi.org/10.1093/nar/gkx1259"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29253179"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29253179"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Di Lu, Lingling Sun, Zhengjun Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "lncRNA EZR‑AS1 knockdown represses proliferation, migration and invasion of cSCC via the PI3K/AKT signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2020.11714"}], "href": "https://doi.org/10.3892/mmr.2020.11714"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33236153"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33236153"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yu Bai, Xian Zhou, Luo Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA EZR-AS1 promotes tumor growth and metastasis by modulating Wnt/β-catenin pathway in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Ther Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/etm.2018.6461"}], "href": "https://doi.org/10.3892/etm.2018.6461"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30186463"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30186463"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Zhenhua Liu, Ning Wang, Feiqing Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Silencing of lncRNA EZR-AS1 inhibits proliferation, invasion, and migration of colorectal cancer cells through blocking transforming growth factor β signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BSR20191199"}], "href": "https://doi.org/10.1042/BSR20191199"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31693738"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31693738"}]}]}]}