{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long non‐coding RNA F11‐AS1 has emerged as a multifunctional regulator with tumor‐suppressive roles in several cancer contexts. In hepatitis B virus (HBV)–related hepatocellular carcinoma, F11‐AS1 is downregulated by the HBx protein; its overexpression reduces cellular proliferation, migration, and invasion while promoting apoptosis by sponging miR‑211‑5p to up‐regulate NR1I3 expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Similarly, in liver hepatocellular carcinoma, F11‐AS1 is underexpressed and functions as a competing endogenous RNA for miR‑3146, thereby enhancing PTEN expression and suppressing tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In addition, reduced expression of F11‐AS1 is included in a seven–lncRNA signature that predicts platinum‑based chemoresistance in high‑grade serous ovarian carcinoma, highlighting its potential value as a prognostic biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Aberrant expression of F11‐AS1 has also been validated in pancreatic ductal adenocarcinoma, suggesting that its dysregulation might serve as a molecular marker for cancer diagnosis and treatment strategies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yibin Deng, Zhongheng Wei, Meijin Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA F11-AS1 inhibits HBV-related hepatocellular carcinoma progression by regulating NR1I3 via binding to microRNA-211-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.14881"}], "href": "https://doi.org/10.1111/jcmm.14881"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31880390"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31880390"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Junkai Du, Mingyue Chen, Jianfei Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA F11-AS1 suppresses liver hepatocellular carcinoma progression by competitively binding with miR-3146 to regulate PTEN expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.29163"}], "href": "https://doi.org/10.1002/jcb.29163"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31168823"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31168823"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jing Song, Wanfeng Zhang, Sen Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A panel of 7 prognosis-related long non-coding RNAs to improve platinum-based chemoresistance prediction in ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2018.4403"}], "href": "https://doi.org/10.3892/ijo.2018.4403"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29749482"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29749482"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xiang Yu, Yang Lin, Wu Sui, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of distinct long noncoding RNA transcriptional fingerprints in pancreatic ductal adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Med (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cam4.1027"}], "href": "https://doi.org/10.1002/cam4.1027"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28220683"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28220683"}]}]}]}