F3 Gene

HGNC Family	CD molecules (CD)
Name	coagulation factor III (thromboplastin, tissue factor)
Description	This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces, for example, on monocytes. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. Platelets and monocytes have been shown to express this coagulation factor under procoagulatory and proinflammatory stimuli, and a major role in HIV-associated coagulopathy has been described. Platelet-dependent monocyte expression of coagulation factor III has been described to be associated with Coronavirus Disease 2019 (COVID-19) severity and mortality. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Aug 2020]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n F3, the gene encoding tissue factor (TF), is the principal cellular initiator of blood coagulation that, upon binding factor VIIa, triggers the proteolytic cascade leading to thrombin generation, fibrin formation, and ultimately clot stabilization."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": " Moreover, TF is expressed not only in subendothelial and vascular wall cells but also by circulating blood elements such as monocytes and activated platelets—which can generate TF through post‐transcriptional processing—and is released in association with microparticles that become enriched within developing thrombi."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "8"}]}, {"type": "t", "text": " Beyond its indispensable role in normal hemostasis, aberrant TF expression and release contribute to pathological thrombosis in conditions such as atherosclerosis, cancer, and sepsis. In these settings TF not only amplifies coagulation but also engages in signaling via protease‐activated receptors (most notably PAR2) to modulate inflammatory responses, angiogenesis, and metastasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "11"}]}, {"type": "t", "text": " In malignancy, for example, tumor cells not only express high levels of TF but also shed TF‐positive microparticles that directly promote thrombus formation and may serve as biomarkers for cancer‐associated thrombosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " Although circulating leukocyte‐derived TF appears to contribute minimally compared with vessel wall TF"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": ", adhesion molecules such as P‐selectin and its ligand PSGL‑1 facilitate the targeted delivery of TF‐bearing microparticles to sites of vascular injury, effectively concentrating TF and promoting thrombus propagation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In summary, F3 functions as a critical interface between coagulation and inflammation. Through its dual capacity to initiate the coagulation cascade and to activate cell signaling pathways, TF is essential for normal hemostasis yet, when dysregulated, becomes a major driver of pathologic thrombosis and inflammatory vascular processes.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Shahrokh Falati, Qingde Liu, Peter Gross, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Accumulation of tissue factor into developing thrombi in vivo is dependent upon microparticle P-selectin glycoprotein ligand 1 and platelet P-selectin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20021868"}], "href": "https://doi.org/10.1084/jem.20021868"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12782720"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12782720"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Nigel Mackman "}, {"type": "b", "children": [{"type": "t", "text": "Role of tissue factor in hemostasis, thrombosis, and vascular development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arterioscler Thromb Vasc Biol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/01.ATV.0000130465.23430.74"}], "href": "https://doi.org/10.1161/01.ATV.0000130465.23430.74"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15117736"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15117736"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Joanne L Yu, Linda May, Vladimir Lhotak, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oncogenic events regulate tissue factor expression in colorectal cancer cells: implications for tumor progression and angiogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2004-05-2042"}], "href": "https://doi.org/10.1182/blood-2004-05-2042"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15494427"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15494427"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jeffrey I Zwicker, Howard A Liebman, Donna Neuberg, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tumor-derived tissue factor-bearing microparticles are associated with venous thromboembolic events in malignancy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-09-0371"}], "href": "https://doi.org/10.1158/1078-0432.CCR-09-0371"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19861441"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19861441"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Kathleen E Brummel, Sara G Paradis, Saulius Butenas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Thrombin functions during tissue factor-induced blood coagulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood.v100.1.148"}], "href": "https://doi.org/10.1182/blood.v100.1.148"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12070020"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12070020"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Ingrid Hrachovinová, Beatrice Cambien, Ali Hafezi-Moghadam, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interaction of P-selectin and PSGL-1 generates microparticles that correct hemostasis in a mouse model of hemophilia A."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm899"}], "href": "https://doi.org/10.1038/nm899"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12858167"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12858167"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Janet Chou, Nigel Mackman, Glenn Merrill-Skoloff, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hematopoietic cell-derived microparticle tissue factor contributes to fibrin formation during thrombus propagation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2004-03-0935"}], "href": "https://doi.org/10.1182/blood-2004-03-0935"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15280200"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15280200"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Jasimuddin Ahamed, Henri H Versteeg, Marjolein Kerver, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Disulfide isomerization switches tissue factor from coagulation to cell signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0606411103"}], "href": "https://doi.org/10.1073/pnas.0606411103"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16959886"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16959886"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Henri H Versteeg, Florence Schaffner, Marjolein Kerver, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of tissue factor signaling suppresses tumor growth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2007-07-101048"}], "href": "https://doi.org/10.1182/blood-2007-07-101048"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17901245"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17901245"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Hansjörg Schwertz, Neal D Tolley, Jason M Foulks, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Signal-dependent splicing of tissue factor pre-mRNA modulates the thrombogenicity of human platelets."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20061302"}], "href": "https://doi.org/10.1084/jem.20061302"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17060476"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17060476"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Tilman M Hackeng, Kristin M Seré, Guido Tans, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Protein S stimulates inhibition of the tissue factor pathway by tissue factor pathway inhibitor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0504240103"}], "href": "https://doi.org/10.1073/pnas.0504240103"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16488980"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16488980"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Julia E Geddings, Nigel Mackman "}, {"type": "b", "children": [{"type": "t", "text": "Tumor-derived tissue factor-positive microparticles and venous thrombosis in cancer patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2013-04-460139"}], "href": "https://doi.org/10.1182/blood-2013-04-460139"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23798713"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23798713"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "E Biró, K N Sturk-Maquelin, G M T Vogel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human cell-derived microparticles promote thrombus formation in vivo in a tissue factor-dependent manner."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Thromb Haemost (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1046/j.1538-7836.2003.00456.x"}], "href": "https://doi.org/10.1046/j.1538-7836.2003.00456.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14738565"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14738565"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Sharlene M Day, Jennifer L Reeve, Brian Pedersen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Macrovascular thrombosis is driven by tissue factor derived primarily from the blood vessel wall."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2004-06-2225"}], "href": "https://doi.org/10.1182/blood-2004-06-2225"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15339841"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15339841"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Bruce Furie, Barbara C Furie "}, {"type": "b", "children": [{"type": "t", "text": "Role of platelet P-selectin and microparticle PSGL-1 in thrombus formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Trends Mol Med (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molmed.2004.02.008"}], "href": "https://doi.org/10.1016/j.molmed.2004.02.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15059608"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15059608"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Katrin J Svensson, Paulina Kucharzewska, Helena C Christianson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hypoxia triggers a proangiogenic pathway involving cancer cell microvesicles and PAR-2-mediated heparin-binding EGF signaling in endothelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1104261108"}], "href": "https://doi.org/10.1073/pnas.1104261108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21788507"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21788507"}]}]}]}
Synonyms	CD142, TF, TFA
Proteins	TF_HUMAN
NCBI Gene ID	2152
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

F3 has 19,489 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 134 datasets.

Click the + buttons to view associations for F3 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

F3 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by F3 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of F3 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of F3 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of F3 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of F3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of F3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of F3 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving F3 protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of F3 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of F3 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of F3 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of F3 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of F3 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of F3 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with F3 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with F3 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of F3 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of F3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of F3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of F3 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of F3 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing F3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing F3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing F3 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing F3 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with F3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with F3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing F3 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of F3 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with F3 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with F3 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with F3 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of F3 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by F3 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DGIdb Drug Targets 2026	interacting drugs for F3 protein from the DGIdb Drug Targets 2026 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with F3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with F3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with F3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with F3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for F3 protein from the curated DrugBank Drug Targets dataset.