{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n FAM138B, a long non‐coding RNA, appears to play a multifaceted role in the regulation of disease processes, particularly in hepatocellular carcinoma (HCC) and endometriosis. In one study, FAM138B was identified as part of a competing endogenous RNA (ceRNA) network in hepatitis B virus‐induced HCC, where it formed an axis with hsa‐miR‐30c to modulate the expression of cell cycle regulators CCNE2 and RRM2, implicating an involvement in the p53 signaling pathway and tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n A separate investigation focusing on HCC reported that linc‐FAM138B expression was reduced in tumor tissues and cell lines; its exosomal form inhibited proliferation, migration, and invasion of HCC cells by sponging miR‐765. This finding not only linked low linc‐FAM138B expression to a poor prognosis in HCC patients but also underscored its tumor‐suppressive function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Additionally, FAM138B has been reported to be significantly downregulated in plasma extracellular vesicles from patients with endometriosis, suggesting its potential utility as a non‐invasive diagnostic biomarker for this condition."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies highlight the important regulatory functions of FAM138B in modulating key signaling pathways in HCC through distinct ceRNA mechanisms, as well as its emerging role in the molecular diagnosis of endometriosis.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jing Xu, Jing Zhang, Fenglian Shan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SSTR5‑AS1 functions as a ceRNA to regulate CA2 by sponging miR‑15b‑5p for the development and prognosis of HBV‑related hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2019.10736"}], "href": "https://doi.org/10.3892/mmr.2019.10736"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31638225"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31638225"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Chenyi Zhuo, Tingzhuang Yi, Jian Pu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exosomal linc-FAM138B from cancer cells alleviates hepatocellular carcinoma progression via regulating miR-765."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.202430"}], "href": "https://doi.org/10.18632/aging.202430"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33401249"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33401249"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Shan Shan, Yeping Yang, Jilan Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Extracellular vesicle-derived long non-coding RNA as circulating biomarkers for endometriosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Reprod Biomed Online (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.rbmo.2021.11.019"}], "href": "https://doi.org/10.1016/j.rbmo.2021.11.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35341703"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35341703"}]}]}]}