| Name | family with sequence similarity 138, member D |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Two recent studies have comprehensively evaluated long non‐coding RNA (lncRNA) profiles in malignant tumors, although neither specifically addressed FAM138D. In a study of retinoblastoma, RNA‐seq analysis revealed widespread transcriptional deregulation of both coding and non‐coding genes, with lncRNAs (for example, DRAIC) emerging as potential modulators of tumor cell growth, suggesting regulatory roles that could impact tumor progression (1). In a separate study focusing on hepatocellular carcinoma, integrated microarray and network-based analyses identified several overexpressed lncRNAs – including FAM182B, SNHG6, SNHG1, and SNHG3 – that were significantly associated with poor prognosis, thereby implicating them in the competitive endogenous RNA (ceRNA) networks underpinning HCC (2). While these investigations have provided insight into the diverse functional roles of lncRNAs in tumor biology, none of the abstracts provided data on the function of FAM138D, leaving its role in oncogenesis to be elucidated in future studies.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n (1)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "(2)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Swetha Rajasekaran, Lakshmi Dhevi Nagarajha Selvan, Kathleen Dotts, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Non-coding and Coding Transcriptional Profiles Are Significantly Altered in Pediatric Retinoblastoma Tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Oncol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fonc.2019.00221"}], "href": "https://doi.org/10.3389/fonc.2019.00221"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31058073"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31058073"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jun Liu, Wenli Li, Jian Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of key genes and long non-coding RNA associated ceRNA networks in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PeerJ (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7717/peerj.8021"}], "href": "https://doi.org/10.7717/peerj.8021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31695969"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31695969"}]}]}]}
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| NCBI Gene ID | 677784 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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FAM138D has 534 functional associations with biological entities spanning 4 categories (molecular profile, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 14 datasets.
Click the + buttons to view associations for FAM138D from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of FAM138D gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of FAM138D gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at FAM138D gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of FAM138D gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of FAM138D gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of FAM138D gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of FAM138D gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of FAM138D gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of FAM138D gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of FAM138D gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of FAM138D gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at FAM138D gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of FAM138D gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of FAM138D protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
