{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n In a study investigating sex‐related differences in lactotroph tumors (as detailed in"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", transcriptomic profiling highlighted that several genes regulated by the estrogen receptor signaling pathway were differentially expressed between men and women. Among these, FAM138F—located on the X chromosome—appears as one of the genes whose altered expression may be linked with key cellular processes such as morphology, growth, proliferation, development, and movement. The differential regulation of FAM138F suggests that it could be contributing to the distinct tumor aggressiveness observed between sexes, with lower estrogen receptor activity potentially underpinning the more aggressive phenotype in male lactotroph tumors. Although the precise functional mechanism of FAM138F is not fully resolved, its association with estrogen pathway–related gene signatures underscores its possible role in mediating the sex-associated differences in tumor behavior.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Anne Wierinckx, Etienne Delgrange, Philippe Bertolino, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sex-Related Differences in Lactotroph Tumor Aggressiveness Are Associated With a Specific Gene-Expression Signature and Genome Instability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Endocrinol (Lausanne) (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fendo.2018.00706"}], "href": "https://doi.org/10.3389/fendo.2018.00706"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30555413"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30555413"}]}]}]}