{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n FAM13A‐AS1 is a long noncoding RNA that has emerged as a multifunctional regulator in several disease contexts. In thyroid cancer, decreased expression of FAM13A‐AS1 is correlated with longer disease‐free survival, suggesting that elevated levels may be linked to tumor progression and an unfavorable prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In renal cell carcinoma, FAM13A‐AS1 is upregulated and functions in an oncogenic manner; knockdown experiments demonstrated that it promotes cell proliferation, migration, and invasion by acting as a competing endogenous RNA (ceRNA) that decoys miR‐141–3p to upregulate NEK6 expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, in clear cell renal cell carcinoma subtyping analyses, alterations in FAM13A‐AS1, together with changes in miR‐145, have been shown to influence key cellular processes including invasion, apoptosis, migration, and metabolic functions, thereby contributing to subtype‐specific phenotypes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Beyond oncogenesis, FAM13A‐AS1 has also been linked to adverse pharmacological effects; in lithium‐treated patients with bipolar disorder, its expression is associated with the incidence of tremor, pointing to a potential role in modulating treatment response."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In addition, its inclusion in an autophagy‐related lncRNA prognostic signature for bladder cancer further emphasizes its potential utility as a biomarker for patient stratification and prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings underscore the diverse roles of FAM13A‐AS1 in regulating tumor growth, metastasis, and therapeutic outcomes, and they highlight its promise as both a prognostic biomarker and a potential target for therapeutic intervention.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yuansheng Rao, Haiying Liu, Xiaojuan Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "In Silico Analysis Identifies Differently Expressed lncRNAs as Novel Biomarkers for the Prognosis of Thyroid Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Comput Math Methods Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2020/3651051"}], "href": "https://doi.org/10.1155/2020/3651051"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32377223"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32377223"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xin Jun Wang, Si Li, Jiang Fang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA FAM13A-AS1 Promotes Renal Carcinoma Tumorigenesis Through Sponging miR-141-3p to Upregulate NEK6 Expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Mol Biosci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fmolb.2022.738711"}], "href": "https://doi.org/10.3389/fmolb.2022.738711"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35402517"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35402517"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yanyan Wu, Weishan Han, Deling Xu, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Dose-dependent transcriptional effects of lithium and adverse effect burden in a psychiatric cohort."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Prog Neuropsychopharmacol Biol Psychiatry (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.pnpbp.2021.110408"}], "href": "https://doi.org/10.1016/j.pnpbp.2021.110408"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34320404"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34320404"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Zhuolun Sun, Changying Jing, Chutian Xiao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An autophagy-related long non-coding RNA prognostic signature accurately predicts survival outcomes in bladder urothelial carcinoma patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.103718"}], "href": "https://doi.org/10.18632/aging.103718"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32805727"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32805727"}]}]}]}