{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n FAM157C has emerged as a long noncoding RNA (lncRNA) of interest in the context of coronary artery disease. In a recent RNA‐sequencing study investigating unstable angina (UA), FAM157C was identified as one of the top ten upregulated lncRNAs in peripheral blood mononuclear cells from UA patients compared to controls with normal coronary arteries, suggesting that its increased expression may serve as a potential biomarker and indicate a role in the disease’s pathogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In contrast, another study focused on using BioNano and nanopore data to explore the structural variability and extension sequences of human chromosome ends did not directly address FAM157C. Rather, this work detailed extensive sub-telomeric duplications and sequence extensions derived from ancestral primate regions, highlighting genomic diversity at chromosome termini."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " \n Thus, while FAM157C’s expression is implicated in the pathology of unstable angina, its functional characterization appears confined to cardiovascular studies rather than the genomic structural variations described in telomeric regions.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sudong Liu, Jingyuan Hou, Xiaodong Gu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of LncRNA expression profile and identification of functional LncRNAs associated with unstable angina."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Lab Anal (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcla.24036"}], "href": "https://doi.org/10.1002/jcla.24036"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34609019"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34609019"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Haojing Shao, Chenxi Zhou, Minh Duc Cao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ongoing human chromosome end extension revealed by analysis of BioNano and nanopore data."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-018-34774-0"}], "href": "https://doi.org/10.1038/s41598-018-34774-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30413723"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30413723"}]}]}]}