{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n A review of the provided abstracts reveals that none of the studies have directly focused on or characterized the function of FAM167A‐AS1. In the fibromyalgia investigation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", a broad agnostic gene expression analysis identified a panel of differentially expressed genes—including FAM167A‐AS1 as part of a diagnostic signature—with pathways implicated in nociceptive processing and inflammation. This finding suggests that FAM167A‐AS1 may be a candidate biomarker linked to maladaptive pain signaling and immune modulation, although its precise molecular role and mechanism of action have not been explored further. The remaining studies"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "2", "end_ref": "5"}]}, {"type": "t", "text": "instead report novel gene associations and genetic modifiers in cystic fibrosis, systemic lupus erythematosus, congenital malformations, and obesity, respectively, but do not specifically address FAM167A‐AS1. In summary, while FAM167A‐AS1 has been incidentally captured as part of a discriminating gene expression signature in fibromyalgia, its function remains to be elucidated, and further studies are needed to clarify whether it plays an active role in disease-related pathways or serves as a surrogate marker for underlying pathophysiological processes.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Kim D Jones, Terri Gelbart, Thomas C Whisenant, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide expression profiling in the peripheral blood of patients with fibromyalgia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Exp Rheumatol (2016)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27157394"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27157394"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Lindsay B Henderson, Vishal K Doshi, Scott M Blackman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Variation in MSRA modifies risk of neonatal intestinal obstruction in cystic fibrosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1002580"}], "href": "https://doi.org/10.1371/journal.pgen.1002580"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22438829"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22438829"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Isaac T W Harley, Kenneth M Kaufman, Carl D Langefeld, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic susceptibility to SLE: new insights from fine mapping and genome-wide association studies."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Rev Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nrg2571"}], "href": "https://doi.org/10.1038/nrg2571"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19337289"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19337289"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Mauro Longoni, Kasper Lage, Meaghan K Russell, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Congenital diaphragmatic hernia interval on chromosome 8p23.1 characterized by genetics and protein interaction networks."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet A (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.a.35665"}], "href": "https://doi.org/10.1002/ajmg.a.35665"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23165946"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23165946"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Karen A Schlauch, Robert W Read, Vincent C Lombardi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Comprehensive Genome-Wide and Phenome-Wide Examination of BMI and Obesity in a Northern Nevadan Cohort."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "G3 (Bethesda) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1534/g3.119.400910"}], "href": "https://doi.org/10.1534/g3.119.400910"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31888951"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31888951"}]}]}]}