{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Integrated analyses across multiple disease contexts have begun to shed light on the potential regulatory roles of long non‐coding RNAs. In particular, FAM170B‑AS1 has emerged as a candidate lncRNA of interest. Differential expression studies in hepatocellular carcinoma (HCC) have identified a spectrum of lncRNAs that appear to influence tumor cell proliferation, invasiveness, and dissemination; FAM170B‑AS1 is among those highlighted as potentially modulating proliferation pathways (see"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "and."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Similarly, in diabetic foot ulcers (DFUs), analyses of differentially expressed lncRNAs have implicated regulatory networks—encompassing components of the ERK cascade, centrosome duplication, and DNA repair processes—that may contribute to tissue repair and wound healing; within this framework, FAM170B‑AS1 is suggested to participate in these regulatory processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, exome‑wide association studies investigating early‑onset coronary artery disease (CAD) have identified genetic variants in non‑coding regions that potentially alter regulatory networks governing vascular function and inflammatory responses, hinting at a role for lncRNAs such as FAM170B‑AS1 in conferring disease susceptibility."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Together, these findings suggest that FAM170B‑AS1 may act as a modulatory molecule within gene expression networks that underlie pathological processes in HCC, DFUs, and CAD. Notwithstanding these promising associations, further mechanistic studies are warranted to fully elucidate the molecular functions of FAM170B‑AS1 and its potential as a therapeutic target.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tiago Falcon, Martiela Freitas, Ana Carolina Mello, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of the Cancer Genome Atlas Data Reveals Novel Putative ncRNAs Targets in Hepatocellular Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2018/2864120"}], "href": "https://doi.org/10.1155/2018/2864120"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30046591"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30046591"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Kangsheng Tu, Qiongzhu Dong, Junyan Tao "}, {"type": "b", "children": [{"type": "t", "text": "Role of ncRNAs in Hepatocellular Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2018/3014543"}], "href": "https://doi.org/10.1155/2018/3014543"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30151377"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30151377"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Pijun Yu, Jian Guo, Junjie Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Co-expression network analysis revealing the key lncRNAs in diabetic foot ulcers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Med Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.5114/aoms.2019.84699"}], "href": "https://doi.org/10.5114/aoms.2019.84699"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31572456"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31572456"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yoshiji Yamada, Yoshiki Yasukochi, Kimihiko Kato, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of 26 novel loci that confer susceptibility to early-onset coronary artery disease in a Japanese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/br.2018.1152"}], "href": "https://doi.org/10.3892/br.2018.1152"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30402224"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30402224"}]}]}]}