{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Two recent studies have shed light on the involvement of the long non‐coding RNA FAM181A‐AS1 in thyroid disease. In one investigation focused on understanding the functional and clinical significance of lncRNAs, FAM181A‐AS1 was among the transcripts examined for its potential role in disease pathogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In a separate study that reviewed machine learning approaches for the early diagnosis of thyroid conditions, FAM181A‐AS1 emerged as part of a panel of RNA features, where its downregulation was specifically associated with papillary thyroid carcinoma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Thus, the reduction in FAM181A‐AS1 expression appears to serve as an important molecular signature within the broader genomic profile of thyroid cancers, supporting its potential utility as a diagnostic biomarker and emphasizing the need for further research into its biological function and clinical relevance.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xin Jiang, Dong Chen "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA FAM181A-AS1 promotes gliomagenesis by sponging miR-129-5p and upregulating ZRANB2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.103391"}], "href": "https://doi.org/10.18632/aging.103391"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33080570"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33080570"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Kwang-Sig Lee, Hyuntae Park "}, {"type": "b", "children": [{"type": "t", "text": "Machine learning on thyroid disease: a review."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Biosci (Landmark Ed) (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.31083/j.fbl2703101"}], "href": "https://doi.org/10.31083/j.fbl2703101"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35345333"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35345333"}]}]}]}