| Name | family with sequence similarity 201, member A |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n FAM201A is a long noncoding RNA that plays diverse roles in both malignant and non‐malignant conditions. In several types of lung cancers—including non‐small cell lung cancer (NSCLC), lung squamous cell carcinoma (LSCC), lung adenocarcinoma (LUAD) and triple‐negative breast cancer (TNBC)—FAM201A is frequently upregulated and associated with aggressive tumor behaviors such as enhanced proliferation, migration, invasion, metastasis, and resistance to radiotherapy. For instance, in NSCLC, FAM201A acts as a competing endogenous RNA (ceRNA) by sponging miR‑370 to elevate EGFR and HIF‑1α levels, thereby promoting radioresistance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In LSCC, silencing FAM201A reduces cell proliferation and metastatic potential through a mechanism involving miR‑101 and subsequent regulation of Vimentin"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ", while in TNBC FAM201A—transcriptionally activated by TCF3—functions by sequestering miR‑186‑5p to upregulate TNKS1BP1."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Similar oncogenic mechanisms are observed in LUAD, where FAM201A contributes to tumor development by targeting miR‑7515 to promote GLO1 expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Conversely, in noncancerous conditions such as osteonecrosis of the femoral head, FAM201A is downregulated and correlates with disease development"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ", and its decreased expression is also associated with an increased susceptibility to atrial fibrillation through a ceRNA network involving miR‑33a‑3p and RAC3."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Collectively, these findings indicate that FAM201A modulates key cellular processes through microRNA sponging and ceRNA mechanisms in a context‐dependent manner, making it a promising biomarker and potential therapeutic target in oncology and other clinical settings.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "A-M Liu, Y Zhu, Z-W Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA FAM201A involves in radioresistance of non-small-cell lung cancer by enhancing EGFR expression via miR-370."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201907_18319"}], "href": "https://doi.org/10.26355/eurrev_201907_18319"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31298332"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31298332"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "L Lu, X-X Xu, Y-Y Bai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA FAM201A promotes lung squamous cell carcinoma progression through interaction with miR-101."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202106_26130"}], "href": "https://doi.org/10.26355/eurrev_202106_26130"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34227092"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34227092"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Hongyao Jia, Di Wu, Zhiru Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TCF3-activated FAM201A enhances cell proliferation and invasion via miR-186-5p/TNKS1BP1 axis in triple-negative breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioorg Chem (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bioorg.2020.104301"}], "href": "https://doi.org/10.1016/j.bioorg.2020.104301"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33011533"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33011533"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jun Huang, Qiuhua Yu, Yanjuan Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FAM201A knockdown inhibits proliferation and invasion of lung adenocarcinoma cells by regulating miR-7515/GLO1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.30250"}], "href": "https://doi.org/10.1002/jcp.30250"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33687075"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33687075"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Gangyong Huang, Guanglei Zhao, Jun Xia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FGF2 and FAM201A affect the development of osteonecrosis of the femoral head after femoral neck fracture."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2018.01.090"}], "href": "https://doi.org/10.1016/j.gene.2018.01.090"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29382571"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29382571"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xi Chen, Xiang-Yu He, Qing Dan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FAM201A, a long noncoding RNA potentially associated with atrial fibrillation identified by ceRNA network analyses and WGCNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Med Genomics (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12920-022-01232-w"}], "href": "https://doi.org/10.1186/s12920-022-01232-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35410298"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35410298"}]}]}]}
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| Synonyms | C9ORF122 |
| Proteins | F201A_HUMAN |
| NCBI Gene ID | 158228 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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FAM201A has 2,260 functional associations with biological entities spanning 6 categories (molecular profile, functional term, phrase or reference, disease, phenotype or trait, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 23 datasets.
Click the + buttons to view associations for FAM201A from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of FAM201A gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of FAM201A gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of FAM201A gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of FAM201A gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of FAM201A gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of FAM201A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of FAM201A gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with FAM201A gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at FAM201A gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of FAM201A gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of FAM201A gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing FAM201A from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of FAM201A gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of FAM201A gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of FAM201A gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of FAM201A gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of FAM201A gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of FAM201A gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of FAM201A gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain FAM201A protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of FAM201A gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at FAM201A gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of FAM201A gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
