{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n FAM222A‐AS1 is a long non‐coding RNA that appears to have context‐dependent regulatory functions. In neural stem cells, FAM222A‐AS1 is classified among short‐lived non‐coding transcripts whose expression is sensitive to various chemical stresses—including oxidative stress, heavy metal exposure, and protein synthesis stress—suggesting that it may play a role in rapid stress response and immediate gene regulatory processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the context of lung adenocarcinoma, FAM222A‐AS1 has been identified as one of six metastasis‐associated lncRNAs whose combined expression pattern constitutes a prognostic signature for predicting tumor relapse. Functional studies in lung adenocarcinoma cells indicate that FAM222A‐AS1 contributes to the regulation of cell mobility, implying that it may facilitate metastatic processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n While additional work is required to delineate the precise molecular mechanisms, the data from these studies highlight the dual role of FAM222A‐AS1: participating in acute cellular responses to stress as well as influencing tumor cell migration and metastasis.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hidenori Tani, Sayaka Okuda, Kaoru Nakamura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Short-lived long non-coding RNAs as surrogate indicators for chemical exposure and LINC00152 and MALAT1 modulate their neighboring genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0181628"}], "href": "https://doi.org/10.1371/journal.pone.0181628"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28719640"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28719640"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiaoshi Zhang, Jingyi Han, Lutao Du, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Unique metastasis-associated lncRNA signature optimizes prediction of tumor relapse in lung adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Thorac Cancer (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/1759-7714.13325"}], "href": "https://doi.org/10.1111/1759-7714.13325"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31994347"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31994347"}]}]}]}