{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nA review of the provided abstracts indicates that none of these studies mention FAM223B or provide any insights into its function. Instead, the articles collectively focus on neuropeptide Y (NPY) and its receptors—especially the Y₁ subtype—and describe their essential roles in a wide array of physiological processes including the regulation of cerebral hemodynamics, bone homeostasis, energy balance, neurogenesis, emotional behavior, and immune as well as metabolic functions."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn these detailed investigations—employing techniques such as genetic ablation, pharmacological modulation, and in situ hybridization—the NPY receptor pathways have been implicated in the modulation of diverse processes ranging from cerebrovascular responses and osteoprogenitor differentiation to stress responsiveness and metabolic regulation. However, across all the abstracts, there is no mention or experimental evidence linking FAM223B to any biological activity or signaling cascade. Consequently, while the NPY system is well characterized in these contexts, the function of FAM223B remains unaddressed and unclear in the current literature."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "19", "end_ref": "30"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nThus, based on the current body of evidence, no functional role can be attributed to FAM223B from these abstracts. Future research explicitly targeting FAM223B is necessary to determine whether it contributes to any of the physiological processes described for the NPY system or if it functions within an entirely distinct cellular pathway."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "31", "end_ref": "39"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Todd E Thiele, Ming Teng Koh, Thierry Pedrazzini "}, {"type": "b", "children": [{"type": "t", "text": "Voluntary alcohol consumption is controlled via the neuropeptide Y Y1 receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2002)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11826154"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11826154"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Alessandra Oberto, Paolo Mele, Francesca Zammaretti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Evidence of altered neuropeptide Y content and neuropeptide Y1 receptor gene expression in the hypothalamus of pregnant transgenic mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrinology (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/en.2003-0197"}], "href": "https://doi.org/10.1210/en.2003-0197"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12960052"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12960052"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Paula D Raposinho, Thierry Pedrazzini, Richard B White, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chronic neuropeptide Y infusion into the lateral ventricle induces sustained feeding and obesity in mice lacking either Npy1r or Npy5r expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrinology (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/en.2003-0914"}], "href": "https://doi.org/10.1210/en.2003-0914"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14525913"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14525913"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Christine Gonzales, Marie-Jeanne Voirol, Marco Giacomini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The neuropeptide Y Y1 receptor mediates NPY-induced inhibition of the gonadotrope axis under poor metabolic conditions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.03-0189fje"}], "href": "https://doi.org/10.1096/fj.03-0189fje"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14597564"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14597564"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Toshiro Kishi, Carl J Aschkenasi, Brian J Choi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neuropeptide Y Y1 receptor mRNA in rodent brain: distribution and colocalization with melanocortin-4 receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Comp Neurol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cne.20432"}], "href": "https://doi.org/10.1002/cne.20432"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15690487"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15690487"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "W Wittmann, S Loacker, I Kapeller, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Y1-receptors regulate the expression of Y2-receptors in distinct mouse forebrain areas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuroscience (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuroscience.2005.07.047"}], "href": "https://doi.org/10.1016/j.neuroscience.2005.07.047"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16198492"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16198492"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Tim Karl, Thomas H J Burne, Herbert Herzog "}, {"type": "b", "children": [{"type": "t", "text": "Effect of Y1 receptor deficiency on motor activity, exploration, and anxiety."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Behav Brain Res (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbr.2005.08.019"}], "href": "https://doi.org/10.1016/j.bbr.2005.08.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16203045"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16203045"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "En-Ju D Lin, Amanda Sainsbury, Nicola J Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Combined deletion of Y1, Y2, and Y4 receptors prevents hypothalamic neuropeptide Y overexpression-induced hyperinsulinemia despite persistence of hyperphagia and obesity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrinology (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/en.2006-0097"}], "href": "https://doi.org/10.1210/en.2006-0097"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16873543"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16873543"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Paul A Baldock, Susan J Allison, Pernilla Lundberg, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel role of Y1 receptors in the coordinated regulation of bone and energy homeostasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M700644200"}], "href": "https://doi.org/10.1074/jbc.M700644200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17491016"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17491016"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Pernilla Lundberg, Susan J Allison, Nicola J Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Greater bone formation of Y2 knockout mice is associated with increased osteoprogenitor numbers and altered Y1 receptor expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M609629200"}], "href": "https://doi.org/10.1074/jbc.M609629200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17491022"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17491022"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Hideki Yuzuriha, Akio Inui, Akihiro Asakawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gastrointestinal hormones (anorexigenic peptide YY and orexigenic ghrelin) influence neural tube development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.06-7621com"}], "href": "https://doi.org/10.1096/fj.06-7621com"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17400914"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17400914"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Alessandra Oberto, Elena Acquadro, Thorsten Bus, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression patterns of promoters for NPY Y(1) and Y(5) receptors in Y(5)RitTA and Y(1)RVenus BAC-transgenic mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Neurosci (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1460-9568.2007.05631.x"}], "href": "https://doi.org/10.1111/j.1460-9568.2007.05631.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17614946"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17614946"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Joana Rosmaninho-Salgado, Inês M Araújo, Ana Rita Alvaro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Intracellular signaling mechanisms mediating catecholamine release upon activation of NPY Y1 receptors in mouse chromaffin cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurochem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1471-4159.2007.04899.x"}], "href": "https://doi.org/10.1111/j.1471-4159.2007.04899.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17868303"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17868303"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Rose-Marie Karlsson, Jessica S Choe, Heather A Cameron, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The neuropeptide Y Y1 receptor subtype is necessary for the anxiolytic-like effects of neuropeptide Y, but not the antidepressant-like effects of fluoxetine, in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Psychopharmacology (Berl) (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00213-007-0945-2"}], "href": "https://doi.org/10.1007/s00213-007-0945-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17891380"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17891380"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Kharen L Doyle, Tim Karl, Yvonne Hort, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Y1 receptors are critical for the proliferation of adult mouse precursor cells in the olfactory neuroepithelium."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurochem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1471-4159.2007.05188.x"}], "href": "https://doi.org/10.1111/j.1471-4159.2007.05188.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18088353"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18088353"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Davor Stanic, Gustavo Paratcha, Fernanda Ledda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Peptidergic influences on proliferation, migration, and placement of neural progenitors in the adult mouse forebrain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0712303105"}], "href": "https://doi.org/10.1073/pnas.0712303105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18305161"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18305161"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Liliana Teixeira, Daniela M Sousa, Ana Filipa Nunes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NPY revealed as a critical modulator of osteoblast function in vitro: new insights into the role of Y1 and Y2 receptors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.22194"}], "href": "https://doi.org/10.1002/jcb.22194"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19459152"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19459152"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "H K Jin, J S Bae, S Furuya, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Amyloid beta-derived neuroplasticity in bone marrow-derived mesenchymal stem cells is mediated by NPY and 5-HT2B receptors via ERK1/2 signalling pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Prolif (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1365-2184.2009.00625.x"}], "href": "https://doi.org/10.1111/j.1365-2184.2009.00625.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19614678"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19614678"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Mickael Decressac, Ben Wright, Belin David, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exogenous neuropeptide Y promotes in vivo hippocampal neurogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hippocampus (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/hipo.20765"}], "href": "https://doi.org/10.1002/hipo.20765"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20095007"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20095007"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "T Karl, R Chesworth, L Duffy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Acoustic startle response and sensorimotor gating in a genetic mouse model for the Y1 receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuropeptides (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.npep.2009.12.008"}], "href": "https://doi.org/10.1016/j.npep.2009.12.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20096928"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20096928"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Nicola J Lee, Kharen L Doyle, Amanda Sainsbury, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Critical role for Y1 receptors in mesenchymal progenitor cell differentiation and osteoblast activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Bone Miner Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jbmr.61"}], "href": "https://doi.org/10.1002/jbmr.61"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20200977"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20200977"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Nicola J Lee, Amy D Nguyen, Ronaldo F Enriquez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Osteoblast specific Y1 receptor deletion enhances bone mass."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bone (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bone.2010.10.174"}], "href": "https://doi.org/10.1016/j.bone.2010.10.174"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21040809"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21040809"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Laurence Macia, Priya T Rao, Julie Wheway, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Y1 signalling has a critical role in allergic airway inflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunol Cell Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/icb.2011.6"}], "href": "https://doi.org/10.1038/icb.2011.6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21383768"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21383768"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "M Martini, M Sica, S Gotti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effects of estrous cycle and sex on the expression of neuropeptide Y Y1 receptor in discrete hypothalamic and limbic nuclei of transgenic mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Peptides (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.peptides.2011.04.004"}], "href": "https://doi.org/10.1016/j.peptides.2011.04.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21514339"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21514339"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "D Verma, R O Tasan, H Herzog, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NPY controls fear conditioning and fear extinction by combined action on Y₁ and Y₂ receptors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Pharmacol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1476-5381.2012.01872.x"}], "href": "https://doi.org/10.1111/j.1476-5381.2012.01872.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22289084"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22289084"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Amy D Nguyen, Natalie F Mitchell, Shu Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Y1 and Y5 receptors are both required for the regulation of food intake and energy homeostasis in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0040191"}], "href": "https://doi.org/10.1371/journal.pone.0040191"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22768253"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22768253"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Laurence Macia, Ernie Yulyaningsih, Laurent Pangon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neuropeptide Y1 receptor in immune cells regulates inflammation and insulin resistance associated with diet-induced obesity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetes (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2337/db12-0156"}], "href": "https://doi.org/10.2337/db12-0156"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23011592"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23011592"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Daniela M Sousa, Michelle M McDonald, Kathy Mikulec, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neuropeptide Y modulates fracture healing through Y1 receptor signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Orthop Res (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jor.22400"}], "href": "https://doi.org/10.1002/jor.22400"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23733357"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23733357"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Angela Longo, Paolo Mele, Ilaria Bertocchi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Conditional inactivation of neuropeptide Y Y1 receptors unravels the role of Y1 and Y5 receptors coexpressing neurons in anxiety."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Psychiatry (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopsych.2014.01.009"}], "href": "https://doi.org/10.1016/j.biopsych.2014.01.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24548641"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24548641"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "S Crnkovic, B Egemnazarov, P Jain, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NPY/Y₁ receptor-mediated vasoconstrictory and proliferative effects in pulmonary hypertension."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Pharmacol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/bph.12751"}], "href": "https://doi.org/10.1111/bph.12751"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24779394"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24779394"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Lili Huang, Hwee Y Tan, Matthew J Fogarty, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Actions of NPY, and its Y1 and Y2 receptors on pulsatile growth hormone secretion during the fed and fasted state."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.4622-13.2014"}], "href": "https://doi.org/10.1523/JNEUROSCI.4622-13.2014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25471570"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25471570"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "A Longo, A Oberto, P Mele, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NPY-Y1 coexpressed with NPY-Y5 receptors modulate anxiety but not mild social stress response in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Brain Behav (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/gbb.12232"}], "href": "https://doi.org/10.1111/gbb.12232"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26178014"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26178014"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Min Hee Park, Jong Kil Lee, Namoh Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neuropeptide Y Induces Hematopoietic Stem/Progenitor Cell Mobilization by Regulating Matrix Metalloproteinase-9 Activity Through Y1 Receptor in Osteoblasts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cells (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/stem.2383"}], "href": "https://doi.org/10.1002/stem.2383"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27090492"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27090492"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Hana Uhlirova, Kıvılcım Kılıç, Peifang Tian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cell type specificity of neurovascular coupling in cerebral cortex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.14315"}], "href": "https://doi.org/10.7554/eLife.14315"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27244241"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27244241"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Daniela M Sousa, Francisco Conceição, Diana I Silva, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ablation of Y1 receptor impairs osteoclast bone-resorbing activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep33470"}], "href": "https://doi.org/10.1038/srep33470"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27646989"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27646989"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Motoki Yahara, Kanchu Tei, Masato Tamura "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of neuropeptide Y Y1 receptor induces osteoblast differentiation in MC3T3‑E1 cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2017.6866"}], "href": "https://doi.org/10.3892/mmr.2017.6866"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28656295"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28656295"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Kim Loh, Yan-Chuan Shi, Mohammed Bensellam, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Y1 receptor deficiency in β-cells leads to increased adiposity and impaired glucose metabolism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-018-30140-2"}], "href": "https://doi.org/10.1038/s41598-018-30140-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30177746"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30177746"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "Ilaria Bertocchi, Alessandra Oberto, Angela Longo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Conditional inactivation of Npy1r gene in mice induces sex-related differences of metabolic and behavioral functions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Horm Behav (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yhbeh.2020.104824"}], "href": "https://doi.org/10.1016/j.yhbeh.2020.104824"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32755609"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32755609"}]}, {"type": "r", "ref": 39, "children": [{"type": "t", "text": "Ilaria Bertocchi, Paolo Mele, Giuliano Ferrero, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NPY-Y1 receptor signaling controls spatial learning and perineuronal net expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuropharmacology (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuropharm.2020.108425"}], "href": "https://doi.org/10.1016/j.neuropharm.2020.108425"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33285203"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33285203"}]}]}]}