{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n FAM225A is a long non‐coding RNA that is frequently upregulated in multiple cancer types including esophageal squamous cell carcinoma, colorectal cancer, gastric cancer, and hepatocellular carcinoma (1,2,3,4,5,6). Elevated FAM225A levels correlate with advanced tumor stage, increased metastasis, and poor patient prognosis. Functionally, FAM225A promotes tumor progression by enhancing cell proliferation, migration, invasion, epithelial–mesenchymal transition, and even chemoresistance. Mechanistically, it acts as a competing endogenous RNA that sponges various microRNAs—for instance, miR‐206, miR‐613, miR‐326, miR‐197‐5p, and miR‐130a‐5p—thereby relieving the inhibitory effects on oncogenic targets such as NETO2, FOXP1, NOTCH3, PADI2, ADAM12, NONO, and CCNG1. This FAM225A‐mediated regulatory network underscores its pivotal role in tumor aggressiveness and highlights its potential as both a prognostic biomarker and a promising therapeutic target.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n ["}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "]\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Chunyu Zhang, Yan Luo, Jingjing Cao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exosomal lncRNA FAM225A accelerates esophageal squamous cell carcinoma progression and angiogenesis via sponging miR-206 to upregulate NETO2 and FOXP1 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cam4.3463"}], "href": "https://doi.org/10.1002/cam4.3463"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33006432"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33006432"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xuexiu Zhang, Haoling Shi, Jianning Yao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FAM225A facilitates colorectal cancer progression by sponging miR-613 to regulate NOTCH3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cam4.3053"}], "href": "https://doi.org/10.1002/cam4.3053"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32343052"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32343052"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xiang Ma, Gang Wang, Hao Fan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA FAM225A promotes the malignant progression of gastric cancer through the miR-326/PADI2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Discov (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41420-021-00809-1"}], "href": "https://doi.org/10.1038/s41420-021-00809-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35017465"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35017465"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Nan Chen, Xuedan Zhu, Yinxing Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The regulatory relationship and function of LncRNA FAM225A-miR-206-ADAM12 in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Transl Res (2021)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34539984"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34539984"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Pengyuan Zhu, Haitao Huang, Shaorui Gu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Noncoding RNA FAM225A Promotes Esophageal Squamous Cell Carcinoma Development and Progression via Sponging MicroRNA-197-5p and Upregulating NONO."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cancer (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/jca.51292"}], "href": "https://doi.org/10.7150/jca.51292"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33442405"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33442405"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yan Tong Liu, Guo Qing Liu, Jing Min Huang "}, {"type": "b", "children": [{"type": "t", "text": "FAM225A promotes sorafenib resistance in hepatocarcinoma cells through modulating miR-130a-5p-CCNG1 interaction network."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BSR20202054"}], "href": "https://doi.org/10.1042/BSR20202054"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33245102"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33245102"}]}]}]}