{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long non‐coding RNA FAM230B, a member of the FAM230 gene family, has emerged as an important regulatory molecule in several human diseases, particularly in various cancers. Elevated FAM230B expression has been observed in papillary thyroid cancer, where it promotes cell migration, invasion, and epithelial‐mesenchymal transition by sponging miR‑378a‑3p and consequently upregulating WNT5A, indicating its oncogenic function and potential as a diagnostic marker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Similarly, in lung adenocarcinoma, FAM230B is significantly increased in tumor tissues and plasma, correlating with larger tumor size and poorer patient survival. These findings suggest that FAM230B may serve as both a diagnostic and prognostic biomarker for lung adenocarcinoma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its role in carcinogenesis, the evolution and genomic organization of the FAM230 family have been highlighted by studies demonstrating that conserved repeat sequences, duplicated and rearranged in low copy repeats of human chromosome 22, give rise to distinct lincRNA gene families, including FAM230B."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, in osteosarcoma, FAM230B localizes predominantly to the cytoplasm and directly interacts with premature miR‑203. By inhibiting miR‑203 maturation, FAM230B facilitates increased cell proliferation, underscoring its role in tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition to its oncogenic activities, FAM230B has been identified within a non‐coding RNA signature associated with early renal damage in hypertensive patients. Its inclusion in a network of ncRNAs regulating pathways important for filtration barrier integrity and tubular reabsorption further broadens its functional relevance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Finally, in gastric cancer, FAM230B acts as a competing endogenous RNA by sponging miR‑27a‑5p, thereby relieving repression of TOP2A and promoting cancer cell proliferation, migration, and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Collectively, these studies underscore the multifaceted role of FAM230B as an oncogenic lncRNA and as a participant in other pathological processes, supporting its potential as a diagnostic biomarker and therapeutic target.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Qinyi Zhou, Jiajia Feng, Shankai Yin, et al. 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