{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nResearch on metabolic regulation has revealed that asprosin—a hormone secreted during fasting—stimulates hepatic glucose production and appetite via activation of the cAMP signaling pathway through its receptor OLFR734. In experiments with knockout mice, ablation of OLFR734 resulted in reduced cAMP levels, diminished glucose production, and enhanced insulin sensitivity, thereby underscoring the receptor’s critical role in maintaining glucose homeostasis during fasting and high‐fat conditions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn a separate study focusing on gene architecture, the long intergenic non-coding RNA (lincRNA) gene FAM230C, located on human chromosome 13, was characterized using bioinformatics approaches. FAM230C was found to embed the Translocation Breakpoint Type A (TBTA) sequence—a composite motif comprising satellite DNA, Alu elements, and AT-rich regions. Notably, eight related lincRNA genes that carry this TBTA signature were identified as duplications of the 3′ half of the FAM230C sequence and are predominantly found in low copy repeat regions near 22q11.2, a chromosomal segment susceptible to genomic rearrangements. In contrast, FAM230C-related genes in other chromosomes, derived from its 5′ half, do not harbor the TBTA motif, highlighting a specificity in lincRNA gene formation and potential implications for chromosomal stability."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Erwei Li, Haili Shan, Liqun Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "OLFR734 Mediates Glucose Metabolism as a Receptor of Asprosin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Metab (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cmet.2019.05.022"}], "href": "https://doi.org/10.1016/j.cmet.2019.05.022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31230984"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31230984"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Nicholas Delihas "}, {"type": "b", "children": [{"type": "t", "text": "A family of long intergenic non-coding RNA genes in human chromosomal region 22q11.2 carry a DNA translocation breakpoint/AT-rich sequence."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0195702"}], "href": "https://doi.org/10.1371/journal.pone.0195702"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29668722"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29668722"}]}]}]}