{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nA novel functional screening approach was employed using endocrine host cells to express candidate preprohormones that require precise posttranslational processing. In this context, FAM237A was identified as a potent, C-terminally cleaved and amidated secreted peptide that specifically activates the G-protein–coupled receptor GPR83, a receptor implicated in central nervous system signaling and regulatory T‐cell function. Its closely related homolog, FAM237B, sharing 64% sequence identity with FAM237A, was shown to undergo similar processing and secretion, resulting in an active ligand that engages GPR83, although with reduced potency."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nThe study underscores the significance of cellular posttranslational modification systems in converting inactive precursors into bioactive hormones capable of precise receptor activation. The comparable yet diminished activity of FAM237B relative to FAM237A highlights how subtle variations in processing efficiency and peptide structure can influence receptor signaling dynamics."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nThese findings not only expand the repertoire of candidate peptide hormones but also illuminate the functional role of FAM237B in modulating GPR83 activity, thereby providing a basis for further exploration into its potential implications in both central nervous system regulation and immune modulation. This innovative approach to hormone discovery illustrates the interplay between bioinformatics‐driven candidate selection and experimental validation in endocrine research."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Nathan A Sallee, Ernestine Lee, Atossa Leffert, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Pilot Screen of a Novel Peptide Hormone Library Identified Candidate GPR83 Ligands."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "SLAS Discov (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/2472555220934807"}], "href": "https://doi.org/10.1177/2472555220934807"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32713278"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32713278"}]}]}]}