{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe provided abstracts collectively investigate the critical cellular pathways regulated by interferon‐stimulated gene 15 (ISG15) and its associated conjugation system, notably focusing on the activity of the ISG15-activating enzyme UBE1L. These studies demonstrate that protein ISGylation plays key roles in a range of biological processes including antiviral defense against diverse viruses (such as vesicular stomatitis, influenza, Sindbis, and others), modulation of immune signaling, regulation of cell cycle progression in hematopoietic progenitors during stress (such as post–bone marrow transplantation), and even aspects of cancer biology such as lung cancer and retinoblastoma progression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nStructural analysis and mutational studies of ISG15 itself have further underscored the importance of key residues in mediating its interaction with the E1 enzyme, reinforcing the necessity of efficient ISGylation for antiviral functions. In parallel, investigations into cellular heterogeneity and noncoding RNA mechanisms (for example, the LINC00202/miR-3619-5p/RIN1 axis in retinoblastoma) broaden the landscape of host defense and tumor regulation, although these studies do not address the molecular functions of other genes such as FAM238C."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nNotably, throughout all of these reports, there is no mention or characterization of FAM238C. While these findings significantly advance our understanding of interferon-induced ISGylation pathways and their biological consequences, they do not provide any insights into the role or function of FAM238C. Therefore, based on the current collection of abstracts, the function of FAM238C remains unaddressed, and further research will be required to elucidate its biological role.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Keun Il Kim, Ming Yan, Oxana Malakhova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ube1L and protein ISGylation are not essential for alpha/beta interferon signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.26.2.472-479.2006"}], "href": "https://doi.org/10.1128/MCB.26.2.472-479.2006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16382139"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16382139"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiaoyan Yin, Xiuli Cong, Ming Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deficiency of a potential 3p21.3 tumor suppressor gene UBE1L (UBA7) does not accelerate lung cancer development in K-rasLA2 mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Lung Cancer (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.lungcan.2008.05.009"}], "href": "https://doi.org/10.1016/j.lungcan.2008.05.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18571763"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18571763"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Caroline Lai, Jessica J Struckhoff, Jana Schneider, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mice lacking the ISG15 E1 enzyme UbE1L demonstrate increased susceptibility to both mouse-adapted and non-mouse-adapted influenza B virus infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.00105-08"}], "href": "https://doi.org/10.1128/JVI.00105-08"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19004958"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19004958"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xiuli Cong, Ming Yan, Xiaoyan Yin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hematopoietic cells from Ube1L-deficient mice exhibit an impaired proliferation defect under the stress of bone marrow transplantation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood Cells Mol Dis (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bcmd.2010.05.009"}], "href": "https://doi.org/10.1016/j.bcmd.2010.05.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20591702"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20591702"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Hesung Now, Joo-Yeon Yoo "}, {"type": "b", "children": [{"type": "t", "text": "AG490 and PF431396 Sensitive Tyrosine Kinase Control the Population Heterogeneity of Basal STAT1 Activity in Ube1l Deficient Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0159453"}], "href": "https://doi.org/10.1371/journal.pone.0159453"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27427993"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27427993"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Nadia V Giannakopoulos, Elena Arutyunova, Caroline Lai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ISG15 Arg151 and the ISG15-conjugating enzyme UbE1L are important for innate immune control of Sindbis virus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.01590-08"}], "href": "https://doi.org/10.1128/JVI.01590-08"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19073728"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19073728"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Guigang Yan, Yi Su, Zhao Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Noncoding RNA LINC00202 Promotes Tumor Progression by Sponging miR-3619-5p in Retinoblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Struct Funct (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1247/csf.18033"}], "href": "https://doi.org/10.1247/csf.18033"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30905893"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30905893"}]}]}]}