{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent integrative genomic analyses have identified FAM241B as a potential regulator of lipid homeostasis. In a genome‐wide association study conducted in an exclusively Indian cohort, novel variants in FAM241B were detected at a sub‐genome‐wide level and exhibited robust associations with two or more quantitative lipid traits. Importantly, regions harboring FAM241B variants were found to be active CpG sites in human subcutaneous adipose tissue, suggesting that epigenetic mechanisms may mediate its regulatory function. Although these variants did not reach conventional GWAS significance, the convergence of genetic and DNA methylation data highlights a putative role for FAM241B in influencing lipid metabolism and, by extension, susceptibility to metabolic diseases."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Khushdeep Bandesh, Gauri Prasad, Anil K Giri, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association study of blood lipids in Indians confirms universality of established variants."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hum Genet (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s10038-019-0591-7"}], "href": "https://doi.org/10.1038/s10038-019-0591-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30911093"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30911093"}]}]}]}