{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nCentrosomal proteins play pivotal roles in orchestrating cell division, with studies on Sas4 and CENPJ/CPAP demonstrating that proper centriole biogenesis is essential for timely mitosis and survival. Loss‐of-function mutations in these genes lead to defective spindle assembly, prolonged prometaphase and a p53‐dependent apoptotic response, as well as genomic instability that underlies conditions such as microcephaly and primordial dwarfism. Although FAM246A is not directly mentioned in these reports, its evolutionary conservation and membership in protein families governing centrosome function suggest that it may similarly contribute to the regulation of centriole duplication and cell cycle progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the developing cerebral cortex, centrosome‐associated factors are required not only for accurate progenitor cell division but also for neuronal migration. Transcriptional control by proneural factors such as Ascl1 has been shown to regulate Cenpj expression, thereby modulating spindle orientation, microtubule stability and primary cilium dynamics. These processes are key for proper neurogenesis, as abnormal cilium disassembly and microtubule stabilization are linked to defects in neuronal positioning and axon extension."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional insights from studies examining interactions with proteins such as WDR62 and the influence of external factors like alcohol further underscore the complexity of the centrosome–cilium nexus. Disruptions in these networks compromise spindle orientation, cell division fidelity and axonal growth; indeed, improper recruitment of centrosomal components and resultant structural alterations in the spindle and growth cones have been implicated in cortical malformation and callosal axon regeneration defects. By analogy, FAM246A may operate within this regulatory framework, contributing to centrosomal integrity, cytoskeletal dynamics and, ultimately, normal neurodevelopment."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hisham Bazzi, Kathryn V Anderson "}, {"type": "b", "children": [{"type": "t", "text": "Acentriolar mitosis activates a p53-dependent apoptosis pathway in the mouse embryo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1400568111"}], "href": "https://doi.org/10.1073/pnas.1400568111"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24706806"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24706806"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Rebecca E McIntyre, Pavithra Lakshminarasimhan Chavali, Ozama Ismail, et al. 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