{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nFAM30A—also known as KIAA0125—is a long non‐coding RNA whose dysregulated expression has emerged as an important biomarker in hematologic malignancies. In acute myeloid leukemia (AML), higher levels of FAM30A are strongly associated with mutations in regulatory genes such as RUNX1, the enrichment of leukemic stem cell signatures, and features of chemoresistance, all of which translate into lower complete remission rates and shorter overall survival. Similarly, in myelodysplastic syndromes (MDS), elevated FAM30A expression independently predicts a poorer outcome, underscoring its potential as a mediator of adverse disease biology and a promising target for risk stratification and therapeutic intervention."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its roles in blood cancers, aberrant FAM30A expression has been detected in certain solid tumors. For example, in odontogenic lesions such as ameloblastoma, FAM30A transcripts are significantly upregulated compared to normal dental follicle tissues. In silico predictions indicate that FAM30A may interact with multiple microRNA families, suggesting that it contributes to tumor pathobiology by modulating gene regulatory networks that govern cell proliferation and migration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Roman Hornung, Vindi Jurinovic, Aarif M N Batcha, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mediation analysis reveals common mechanisms of RUNX1 point mutations and RUNX1/RUNX1T1 fusions influencing survival of patients with acute myeloid leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-018-29593-2"}], "href": "https://doi.org/10.1038/s41598-018-29593-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30050054"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30050054"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yu-Hung Wang, Chien-Chin Lin, Chia-Lang Hsu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Distinct clinical and biological characteristics of acute myeloid leukemia with higher expression of long noncoding RNA KIAA0125."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Hematol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00277-020-04358-y"}], "href": "https://doi.org/10.1007/s00277-020-04358-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33225420"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33225420"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Sheng-Yu Hung, Chien-Chin Lin, Chia-Lang Hsu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The expression levels of long non-coding RNA KIAA0125 are associated with distinct clinical and biological features in myelodysplastic syndromes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Haematol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/bjh.17231"}], "href": "https://doi.org/10.1111/bjh.17231"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33249572"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33249572"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Marina Gonçalves Diniz, Josiane Alves França, Fabrício A S Vilas-Boas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The long noncoding RNA KIAA0125 is upregulated in ameloblastomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Res Pract (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.prp.2018.12.030"}], "href": "https://doi.org/10.1016/j.prp.2018.12.030"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30595406"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30595406"}]}]}]}