{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent genomic investigations have begun to uncover potential roles for FAM66A in human disease pathogenesis and clinical outcomes. In a study of copy number variants in African Americans with type 2 diabetes–associated end‐stage renal disease, a significant CNV insertion on chromosome 1—within which FAM66A is located—was identified. This finding raises the possibility that genomic alterations affecting FAM66A may contribute to disease susceptibility."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, improvements in epigenomic profiling techniques have emphasized the importance of accurately parsing genomic regions for true biological signals. In one study, careful attention to artifacts in DNA methylation measurements underscored the need to correctly identify modifications in regions that may include important genes such as FAM66A, thereby ensuring that epigenetic alterations are not misinterpreted."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Notably, expression analyses in small cell lung cancer have revealed that high levels of FAM66A, as part of a six‐gene prognostic signature, are associated with poorer overall survival. This suggests that FAM66A may serve as an important marker for aggressive disease and could potentially inform personalized treatment strategies in this cancer subtype."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In summary, although the precise biological function of FAM66A remains to be fully elucidated, current evidence indicates that it may play a multifaceted role in both metabolic and neoplastic disorders. Its involvement in genomic alterations and prognostic outcomes underscores the potential of FAM66A as a biomarker in precision medicine.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jessica N Cooke Bailey, Lingyi Lu, Jeff W Chou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Role of Copy Number Variation in African Americans with Type 2 Diabetes-Associated End Stage Renal Disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Genet Med (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4172/1747-0862.1000061"}], "href": "https://doi.org/10.4172/1747-0862.1000061"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24707315"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24707315"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Wanding Zhou, Timothy J Triche, Peter W Laird, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SeSAMe: reducing artifactual detection of DNA methylation by Infinium BeadChips in genomic deletions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gky691"}], "href": "https://doi.org/10.1093/nar/gky691"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30085201"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30085201"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Shicheng Feng, Xiuxiu Zhang, Xuyu Gu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Six Novel Prognostic Gene Signatures as Potential Biomarkers in Small Cell Lung Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Comb Chem High Throughput Screen (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2174/1386207325666220427121619"}], "href": "https://doi.org/10.2174/1386207325666220427121619"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35490316"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35490316"}]}]}]}