| Name | family with sequence similarity 74, member A3 |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n FAM74A3 is a long non‐coding RNA that has emerged as a potential biomarker in different disease settings. In breast cancer, FAM74A3 is part of a nine‐lncRNA signature whose upregulation correlates with an increased risk of tumor recurrence, suggesting a prognostic role in disease progression (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, transcriptomic analyses in medial temporal lobe epilepsy have identified FAM74A3 among the differentially expressed lncRNAs, where co‐expression network studies implicated it in the regulation of transcription, inflammatory responses, and key signaling pathways such as Jak/Stat and MAPK (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Although its precise mechanistic functions remain to be fully elucidated, the altered expression of FAM74A3 in both cancer and neurological disorders points towards its significant role in modulating cellular processes that might affect disease outcome (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " These findings, together with related studies identifying critical lncRNAs involved in tumor growth and chemoresistance in breast cancer (see"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", support the notion that FAM74A3 warrants further investigation as a candidate prognostic and therapeutic biomarker.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hairong Liu, Juan Li, Pratirodh Koirala, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNAs as prognostic markers in human breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.7828"}], "href": "https://doi.org/10.18632/oncotarget.7828"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26942882"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26942882"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Song Qiao, Qi Xu, Lin Cheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrated analysis of differentially expressed lncRNAs in Medial Temporal Lobe Epilepsy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuro Endocrinol Lett (2018)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30183206"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30183206"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Andrew J Warburton, David N Boone "}, {"type": "b", "children": [{"type": "t", "text": "Insights from Global Analyses of Long Noncoding RNAs in Breast Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Pathobiol Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s40139-017-0122-1"}], "href": "https://doi.org/10.1007/s40139-017-0122-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28616363"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28616363"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yudong Li, Baoxiao Wang, Hongna Lai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA CRALA is associated with poor response to chemotherapy in primary breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Thorac Cancer (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/1759-7714.12487"}], "href": "https://doi.org/10.1111/1759-7714.12487"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28834648"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28834648"}]}]}]}
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| Proteins | F74A3_HUMAN |
| NCBI Gene ID | 728495 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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FAM74A3 has 438 functional associations with biological entities spanning 5 categories (molecular profile, functional term, phrase or reference, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 17 datasets.
Click the + buttons to view associations for FAM74A3 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of FAM74A3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of FAM74A3 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CellMarker Gene-Cell Type Associations | cell types associated with FAM74A3 gene from the CellMarker Gene-Cell Type Associations dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing FAM74A3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of FAM74A3 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at FAM74A3 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of FAM74A3 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of FAM74A3 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of FAM74A3 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of FAM74A3 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of FAM74A3 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of FAM74A3 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of FAM74A3 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain FAM74A3 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of FAM74A3 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of FAM74A3 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of FAM74A3 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
