{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n FAM83C‐AS1 is a long non‐coding RNA that has emerged as an oncogenic regulator in gastrointestinal tumors. In colon cancer, elevated levels of FAM83C‐AS1 are significantly associated with advanced pathological features and correlate with poor overall and disease‐free survival, suggesting its value as both a diagnostic and prognostic biomarker. In addition, gene set enrichment analyses imply that FAM83C‐AS1 is involved in immune‐related pathways, as its expression is linked to the infiltration of dendritic cells and T helper cells and may even predict response to immunotherapy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In colorectal cancer, FAM83C‐AS1 has been shown to exert oncogenic effects by downregulating the tumor suppressor gene SEMA3F. Mechanistically, FAM83C‐AS1 promotes the enrichment of the repressive H3K27me3 mark on the SEMA3F promoter through the upregulation of EZH2. This process is further facilitated by the recruitment of the EZH2‐stabilizing factor ZRANB1, collectively contributing to the malignant transformation of colorectal cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Although studies in glioblastoma have primarily focused on oncogenes such as PLAGL2 that enforce stem cell–like characteristics by modulating pathways like Wnt/β‐catenin"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ",\n the emerging role of FAM83C‐AS1 in gastrointestinal tumors reinforces the concept that non‐coding RNAs can critically influence tumor behavior by regulating both cell–intrinsic oncogenic pathways and the tumor immune microenvironment.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Guanghui Li, Hao Feng, Qing Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of immune infiltration-related LncRNA FAM83C-AS1 for predicting prognosis and immunotherapy response in colon cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transpl Immunol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.trim.2021.101481"}], "href": "https://doi.org/10.1016/j.trim.2021.101481"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34624486"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34624486"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Weinan Xue, Fan Wang, Peng Han, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The oncogenic role of LncRNA FAM83C-AS1 in colorectal cancer development by epigenetically inhibits SEMA3F via stabilizing EZH2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.103835"}], "href": "https://doi.org/10.18632/aging.103835"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33109776"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33109776"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Hongwu Zheng, Haoqiang Ying, Ruprecht Wiedemeyer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and gliomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccr.2010.03.020"}], "href": "https://doi.org/10.1016/j.ccr.2010.03.020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20478531"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20478531"}]}]}]}