{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n FAM87A, a long non‐coding RNA, has been implicated as a functionally significant component of competing endogenous RNA (ceRNA) networks in several disease contexts. In tongue squamous cell carcinoma, FAM87A was identified among a panel of novel lncRNAs with potential prognostic value, suggesting it might serve as a biomarker for disease outcome."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In glioma, FAM87A is notably downregulated; experimental evidence indicates that it acts as a ceRNA by binding to miR‑424‑5p. This interaction modulates the expression of the target gene PPM1H and, consequently, influences key cellular processes including proliferation, migration, and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, an integrative ceRNA network analysis in aortic dissection has predicted that FAM87A may regulate critical genes such as E2F2 and IGF1R by interacting with miR‑31‑5p, miR‑7‑5p, and miR‑16‑5p."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Overall, these findings suggest that FAM87A plays a dual role as both a potential prognostic biomarker and a functional regulator of gene expression via ceRNA mechanisms in diverse pathological settings, particularly in cancer and vascular diseases.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Shusen Zhang, Ruoyan Cao, Qiulan Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive analysis of lncRNA-associated competing endogenous RNA network in tongue squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PeerJ (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7717/peerj.6397"}], "href": "https://doi.org/10.7717/peerj.6397"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30755833"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30755833"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hua Xu, Haiping Zhang, Lina Tan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FAM87A as a Competing Endogenous RNA of miR-424-5p Suppresses Glioma Progression by Regulating PPM1H."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Comput Math Methods Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2021/7952922"}], "href": "https://doi.org/10.1155/2021/7952922"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34712356"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34712356"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Hao Zhang, Ce Bian, Simei Tu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrated analysis of lncRNA-miRNA-mRNA ceRNA network in human aortic dissection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Genomics (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12864-021-08012-3"}], "href": "https://doi.org/10.1186/s12864-021-08012-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34620091"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34620091"}]}]}]}