{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nAlthough none of the provided studies directly describe FAM90A16, emerging evidence from these diverse investigations highlights the critical role of microRNA‐dependent regulation in a variety of cellular processes—processes within which FAM90A16 may eventually be implicated. For example, in megakaryocytes and platelets, the Dicer1‐dependent maturation of microRNAs is essential for maintaining appropriate mRNA levels of key integrin subunits and thereby modulating hemostatic function (1). In a related developmental context, altered gene expression following p53 deletion in mouse embryos suggests that the disruption of microRNA networks can contribute to major congenital defects, hinting at the possibility that FAM90A16, if part of such networks, might influence embryonic development (2).\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSimilarly, in inflammatory and tissue remodeling settings, dysregulation of specific microRNAs has been found to influence the progression of intracerebral hemorrhage and infected bone nonunion, as well as to modulate cardiac fibrosis. These studies underscore the importance of precise post‐transcriptional regulation—mediated by microRNAs targeting key pathway components such as TGFβ signaling—in pathological processes including inflammation, impaired bone healing, and fibrotic remodeling (3, 4, 5). Although FAM90A16 is not directly mentioned in these reports, its potential inclusion within these complex regulatory networks could position it as an as‐yet-uncharacterized mediator or modulator in similar contexts.\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition, the study of microRNAs in melanoma progression further supports the idea that microRNA‐regulated genes play significant roles in tumor development and therapy resistance (6). While the functional role of FAM90A16 remains to be elucidated, the breadth of microRNA‐based regulation documented in these abstracts suggests that investigating FAM90A16 expression, regulation, and downstream effects may reveal novel insights into both normal cellular function and disease pathogenesis."}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jesse W Rowley, Stéphane Chappaz, Aurélie Corduan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dicer1-mediated miRNA processing shapes the mRNA profile and function of murine platelets."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2015-07-661371"}], "href": "https://doi.org/10.1182/blood-2015-07-661371"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26773046"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26773046"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hiromi Hosako, Gail S Martin, Marianne Barrier, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gene and microRNA expression in p53-deficient day 8.5 mouse embryos."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Birth Defects Res A Clin Mol Teratol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/bdra.20565"}], "href": "https://doi.org/10.1002/bdra.20565"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19229884"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19229884"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Hao Nie, Yang Hu, Wenliang Guo, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Transcriptome sequencing profiling identifies miRNA-331-3p as an osteoblast-specific miRNA in infected bone nonunion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bone (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bone.2020.115619"}], "href": "https://doi.org/10.1016/j.bone.2020.115619"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32858253"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32858253"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Fatemeh Yousefi, Bahram M Soltani, Shahram Rabbani "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA‑331 inhibits isoproterenol‑induced expression of profibrotic genes in cardiac myofibroblasts via the TGFβ/smad3 signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-021-82226-z"}], "href": "https://doi.org/10.1038/s41598-021-82226-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33510328"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33510328"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Qun Xie, Ruirui Zhang, Dandan Liu, et al. 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