{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long non‐coding RNAs (lncRNAs) have emerged as key regulators in diverse pathological conditions, including both cancer and autoimmune disorders. In malignant diseases, several lncRNAs are implicated in processes such as lymph node metastasis and tumor recurrence in papillary thyroid carcinoma, cervical cancer, and oral squamous cell carcinoma."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " In contrast, recent transcriptomic and clinical analyses in rheumatoid arthritis (RA) have identified FAM95B1 as a differentially expressed lncRNA in peripheral blood mononuclear cells, with its aberrant expression strongly correlating with clinical measures such as disease duration, joint swelling, and tenderness."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " This finding suggests that, while lncRNAs broadly contribute to tumor biology, FAM95B1 may serve as a promising biomarker for RA diagnosis and disease monitoring, thereby expanding the landscape of lncRNA functionality beyond oncology to include inflammatory and autoimmune pathologies.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Na Li, Mingming Cui, Ping Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Correlations of lncRNAs with cervical lymph node metastasis and prognosis of papillary thyroid carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Onco Targets Ther (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/OTT.S191700"}], "href": "https://doi.org/10.2147/OTT.S191700"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30863094"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30863094"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Lei Zhang, Xiang Meng, Xin-Wei Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNAs in Oral squamous cell carcinoma: biologic function, mechanisms and clinical implications."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12943-019-1021-3"}], "href": "https://doi.org/10.1186/s12943-019-1021-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31133028"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31133028"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yan Zhang, Xing Zhang, Haixia Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Potential Prognostic Long Non-Coding RNA Biomarkers for Predicting Recurrence in Patients with Cervical Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Manag Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/CMAR.S231796"}], "href": "https://doi.org/10.2147/CMAR.S231796"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32099468"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32099468"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yan Long, Jian Liu, Hui Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Network analysis and transcriptome profiling in peripheral blood mononuclear cells of patients with rheumatoid arthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Ther Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/etm.2020.9601"}], "href": "https://doi.org/10.3892/etm.2020.9601"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33456537"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33456537"}]}]}]}