{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n In a recent review on the early diagnosis of thyroid disease, FAM95C was identified as one of several RNA biomarkers whose expression is altered in thyroid pathology, particularly in papillary thyroid carcinoma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " The study, which evaluated diverse data types using machine learning techniques, noted that FAM95C is downregulated in affected tissue. Although the specific molecular function of FAM95C was not elaborated upon, its decreased expression was among the key RNA features associated with the malignancy of thyroid nodules, suggesting that it may serve as a diagnostic indicator in the context of thyroid carcinogenesis. This finding highlights FAM95C’s potential role as a biomarker that, when combined with clinical, radiomic, and other genomic features, could enhance the early detection and prognostic assessment of thyroid disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Kwang-Sig Lee, Hyuntae Park "}, {"type": "b", "children": [{"type": "t", "text": "Machine learning on thyroid disease: a review."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Biosci (Landmark Ed) (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.31083/j.fbl2703101"}], "href": "https://doi.org/10.31083/j.fbl2703101"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35345333"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35345333"}]}]}]}