FAM98A Gene

Name	family with sequence similarity 98, member A
Description	Enables protein methyltransferase activity. Involved in positive regulation of cell population proliferation; positive regulation of gene expression; and protein methylation. Predicted to be part of tRNA-splicing ligase complex. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Family with sequence similarity 98 member A (FAM98A) has emerged as a multifunctional protein in human cells with roles that extend from the regulation of stress responses to the promotion of cancer progression. In several studies, FAM98A was found to be post‐translationally modified by Protein Arginine Methyltransferase 1 (PRMT1), and together with its structural homolog FAM98B, it forms a complex that is important for the maintenance of PRMT1 expression and oncogenic signaling in ovarian cancer cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In endometrial carcinoma, FAM98A is overexpressed and its upregulation—controlled by regulatory non-coding RNAs such as miR-142-3p and circ-IFT80/miR-545-3p—correlates with enhanced cell proliferation, reduced apoptosis, and poor patient prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, in breast cancer, downregulation of FAM98A via miR-26a results in decreased proliferation, invasion, and chemotherapy resistance, further supporting its role as an oncogene."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In colorectal cancer and non‐small cell lung cancer, upregulation of FAM98A is associated with increased cell proliferation and drug resistance, with mechanistic insights suggesting that FAM98A promotes survival pathways—partly through its participation in stress granule dynamics—in response to chemotherapeutic insults."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition to its role in cancer, a genome‐wide association study identified a single nucleotide polymorphism in FAM98A as interacting with insulin secretion loci to contribute to type 2 diabetes susceptibility, suggesting a broader impact on metabolic regulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Furthermore, studies on the cellular stress response have identified FAM98A as a novel component of stress granules; its C-terminal low-complexity region is critical for its localization and assembly within these ribonucleoprotein structures, implicating it in the regulation of RNA fate during cellular stress."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Finally, bioinformatic and evolutionary analyses have placed FAM98A within a novel protein family that shares features with kinetochore components (NDC80/NUF2) and intraflagellar transport proteins, hinting at potential roles in microtubule-associated processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings indicate that FAM98A is involved in the integration of stress responses, RNA regulation, and cell proliferation, thereby contributing to tumor progression and chemoresistance in multiple cancer types while also potentially influencing metabolic processes.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Khondker Ayesha Akter, Mohammed A Mansour, Toshinori Hyodo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FAM98A associates with DDX1-C14orf166-FAM98B in a novel complex involved in colorectal cancer progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biochem Cell Biol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biocel.2016.12.013"}], "href": "https://doi.org/10.1016/j.biocel.2016.12.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28040436"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28040436"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Khondker Ayesha Akter, Mohammed A Mansour, Toshinori Hyodo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FAM98A is a novel substrate of PRMT1 required for tumor cell migration, invasion, and colony formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-015-4310-5"}], "href": "https://doi.org/10.1007/s13277-015-4310-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26503212"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26503212"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Zenghui Li, Ning Li, Xiaomei Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FAM98A promotes cancer progression in endometrial carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-019-03556-1"}], "href": "https://doi.org/10.1007/s11010-019-03556-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31114934"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31114934"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Na Wang, Yunfeng Guo, Liqin Song, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA intraflagellar transport 80 facilitates endometrial cancer progression through modulating miR-545-3p/FAM98A signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Gynecol Oncol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3802/jgo.2022.33.e2"}], "href": "https://doi.org/10.3802/jgo.2022.33.e2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34783205"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34783205"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Tan Liu, Ziming Wang, Menghao Dong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-26a inhibits cell proliferation and invasion by targeting FAM98A in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Lett (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ol.2021.12628"}], "href": "https://doi.org/10.3892/ol.2021.12628"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33747224"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33747224"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Zhanke He, Junbo Yang, Chuyang Sui, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FAM98A promotes resistance to 5-fluorouracil in colorectal cancer by suppressing ferroptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Biochem Biophys (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.abb.2022.109216"}], "href": "https://doi.org/10.1016/j.abb.2022.109216"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35421356"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35421356"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Rui Zheng, Quanbo Liu, Tianxu Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FAM98A promotes proliferation of non-small cell lung cancer cells via the P38-ATF2 signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Manag Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/CMAR.S163323"}], "href": "https://doi.org/10.2147/CMAR.S163323"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30100758"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30100758"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Jacob M Keaton, Jacklyn N Hellwege, Maggie C Y Ng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GENOME-WIDE INTERACTION WITH SELECTED TYPE 2 DIABETES LOCI REVEALS NOVEL LOCI FOR TYPE 2 DIABETES IN AFRICAN AMERICANS."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pac Symp Biocomput (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1142/9789813207813_0024"}], "href": "https://doi.org/10.1142/9789813207813_0024"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27896979"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27896979"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Kanako Ozeki, Mai Sugiyama, Khondker Ayesha Akter, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FAM98A is localized to stress granules and associates with multiple stress granule-localized proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-018-3397-6"}], "href": "https://doi.org/10.1007/s11010-018-3397-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29992460"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29992460"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Kenneth B Schou, Jens S Andersen, Lotte B Pedersen "}, {"type": "b", "children": [{"type": "t", "text": "A divergent calponin homology (NN-CH) domain defines a novel family: implications for evolution of ciliary IFT complex B proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioinformatics (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/bioinformatics/btt661"}], "href": "https://doi.org/10.1093/bioinformatics/btt661"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24257188"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24257188"}]}]}]}
Proteins	FA98A_HUMAN
NCBI Gene ID	25940
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

FAM98A has 6,495 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 108 datasets.

Click the + buttons to view associations for FAM98A from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

FAM98A Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of FAM98A gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of FAM98A gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of FAM98A gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of FAM98A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of FAM98A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of FAM98A gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of FAM98A gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of FAM98A gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of FAM98A gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of FAM98A gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of FAM98A gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with FAM98A protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with FAM98A gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of FAM98A gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of FAM98A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of FAM98A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing FAM98A protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of FAM98A gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing FAM98A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing FAM98A protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing FAM98A protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with FAM98A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with FAM98A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of FAM98A gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with FAM98A gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with FAM98A gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by FAM98A gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with FAM98A gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with FAM98A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with FAM98A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with FAM98A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at FAM98A gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of FAM98A gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of FAM98A gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing FAM98A from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with FAM98A gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of FAM98A gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing FAM98A from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of FAM98A gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of FAM98A gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.