{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n FAM99A is a long non‐coding RNA that plays multifaceted roles in modulating cell behavior in both pregnancy‐related disorders and cancer. In the context of preeclampsia, decreased FAM99A levels in placental tissues have been associated with impaired trophoblast function—characterized by reduced invasion and migration, increased apoptosis via upregulation of pro‐apoptotic factors (e.g., cleaved caspase‑3, caspase‑9, and Bax) as well as decreased anti‐apoptotic Bcl‑2, and inhibition of Wnt/β‑catenin signaling—whereas overexpression of FAM99A promotes trophoblast survival and metastasis through mechanisms that include sponging miR‑134‑5p to upregulate YAP1."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " In addition, genetic variants within FAM99A have been linked to maternal blood pressure regulation, supporting its potential as a diagnostic marker in hypertensive disorders of pregnancy. In hepatocellular carcinoma, emerging evidence indicates that FAM99A is associated with metastatic behavior and may interact with signaling pathways such as JAK2/STAT3 to affect GLUT1‐mediated glycolysis, thereby influencing tumor progression and therapeutic response."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Collectively, these findings underscore a dual role for FAM99A as a regulator of cell invasion, apoptosis, and metabolism in both gestational and oncological settings, suggesting that it may provide a promising target for diagnostic and therapeutic strategies.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tongqiang He, Yuan Qiao, Yanxiang Lv, et al. "}, {"type": "b", "children": [{"type": "t", "text": "lncRNA FAM99A is downregulated in preeclampsia and exerts a regulatory effect on trophoblast cell invasion, migration and apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2019.10350"}], "href": "https://doi.org/10.3892/mmr.2019.10350"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31173227"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31173227"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Bingnv Xu, Xiaofang Geng, Xiaodan Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA FAM99A modulated YAP1 to affect trophoblast cell behaviors in preeclampsia by sponging miR-134-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Braz J Med Biol Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1590/1414-431X20209732"}], "href": "https://doi.org/10.1590/1414-431X20209732"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33111745"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33111745"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Qiuyan Ge, Ju Zhao, Fujuan Qu "}, {"type": "b", "children": [{"type": "t", "text": "Expression of serum long noncoding RNA FAM99A in patients with hypertensive disorder complicating and its clinical significance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood Press Monit (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/MBP.0000000000000591"}], "href": "https://doi.org/10.1097/MBP.0000000000000591"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35258024"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35258024"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xia Zheng, Yudong Gou, Ziyu Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Icaritin-Induced FAM99A Affects GLUT1-Mediated Glycolysis "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "via"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Regulating the JAK2/STAT3 Pathway in Hepatocellular Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fonc.2021.740557"}], "href": "https://doi.org/10.3389/fonc.2021.740557"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34765550"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34765550"}]}]}]}