{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n FAM99B is a long non‐coding RNA that appears to function as a tumor suppressor and may also play a role in glycemic regulation. In hepatocellular carcinoma (HCC), FAM99B is downregulated compared with adjacent normal tissues, and its lower expression is associated with features of aggressive disease—such as vascular invasion, advanced histologic grade, and higher T stage—as well as poorer overall survival. Functional studies have shown that restoring FAM99B expression in HCC cell lines can significantly inhibit cell proliferation, migration, and invasion. Pathway analyses further suggest that FAM99B is co-expressed with genes involved in metabolic pathways and blood coagulation, indicating potential mechanistic links to tumor metabolism and microenvironment regulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, genetic association studies have implicated the FAM99B locus in metabolic traits. Specifically, variants at this locus have been associated with alterations in HbA1c levels, suggesting that FAM99B might also contribute to the regulation of glucose metabolism and thereby influence the risk of type 2 diabetes mellitus and coronary artery disease in certain populations."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " \n "}]}, {"type": "t", "text": "\n\n "}, {"type": "p", "children": [{"type": "t", "text": "\n These findings, along with broader investigations into the functions of long non-coding RNAs in cancer and gene regulation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", suggest that FAM99B may represent a promising therapeutic target and biomarker, with dual relevance in tumor suppression for HCC and in modulating metabolic risk factors.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Meile Mo, Shun Liu, Xiaoyun Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A liver-specific lncRNA, FAM99B, suppresses hepatocellular carcinoma progression through inhibition of cell proliferation, migration, and invasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cancer Res Clin Oncol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00432-019-02954-8"}], "href": "https://doi.org/10.1007/s00432-019-02954-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31243545"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31243545"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Wael Osman, Ahmed Hassoun, Herbert F Jelinek, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetics of type 2 diabetes and coronary artery disease and their associations with twelve cardiometabolic traits in the United Arab Emirates population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2020.144722"}], "href": "https://doi.org/10.1016/j.gene.2020.144722"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32360841"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32360841"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Florent Hubé, Claire Francastel "}, {"type": "b", "children": [{"type": "t", "text": "Mammalian introns: when the junk generates molecular diversity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms16034429"}], "href": "https://doi.org/10.3390/ijms16034429"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25710723"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25710723"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Davide Degli Esposti, Hector Hernandez-Vargas, Catherine Voegele, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of novel long non-coding RNAs deregulated in hepatocellular carcinoma using RNA-sequencing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.7364"}], "href": "https://doi.org/10.18632/oncotarget.7364"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26887054"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26887054"}]}]}]}