FANCG Gene

HGNC Family	Fanconi anemia, complementation groups (FANC)
Name	Fanconi anemia, complementation group G
Description	The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group G. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n FANCG is a multifunctional protein that plays several critical roles in maintaining genome stability through its participation in the Fanconi anemia (FA) pathway and its close collaboration with homologous recombination (HR) repair factors. As a core component of the multisubunit FA complex, FANCG helps to promote the monoubiquitination of FANCD2—a pivotal step for triggering interstrand cross‐link repair—and it also contributes to complex assembly by bridging interactions between other FA proteins such as FANCA and FANCF (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, FANCG has been shown to directly interact with BRCA2 and is required for the proper formation of a repair complex that includes FANCD2 and RAD51 paralogs; this interaction is regulated by posttranslational modifications (for example, phosphorylation at serine 7) and is essential for efficient HR‐mediated repair of DNA double‐strand breaks and for promoting single‐strand annealing activities (see."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "6"}]}, {"type": "t", "text": " Furthermore, biochemical evidence indicates that FANCG can stimulate the strand exchange and single‐strand annealing activities of FANCA, highlighting its contributory role in processing DNA lesions independent of the canonical FA pathway (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Finally, studies in murine models have revealed that loss of Fancg leads to defects in mesenchymal stem/progenitor cell function, which subsequently impairs the bone marrow microenvironment’s ability to support hematopoietic stem cell engraftment and normal hematopoiesis (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Koji Nakanishi, Yun-Gui Yang, Andrew J Pierce, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0407796102"}], "href": "https://doi.org/10.1073/pnas.0407796102"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15650050"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15650050"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Susan M Gordon, Manuel Buchwald "}, {"type": "b", "children": [{"type": "t", "text": "Fanconi anemia protein complex: mapping protein interactions in the yeast 2- and 3-hybrid systems."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2002-11-3517"}], "href": "https://doi.org/10.1182/blood-2002-11-3517"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12649160"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12649160"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Orna Levran, Claire Attwooll, Rashida T Henry, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The BRCA1-interacting helicase BRIP1 is deficient in Fanconi anemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng1624"}], "href": "https://doi.org/10.1038/ng1624"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16116424"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16116424"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Shobbir Hussain, James B Wilson, Annette L Medhurst, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddh135"}], "href": "https://doi.org/10.1093/hmg/ddh135"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15115758"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15115758"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Kazuhiko Yamamoto, Masamichi Ishiai, Nobuko Matsushita, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Fanconi anemia FANCG protein in mitigating radiation- and enzyme-induced DNA double-strand breaks by homologous recombination in vertebrate cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.23.15.5421-5430.2003"}], "href": "https://doi.org/10.1128/MCB.23.15.5421-5430.2003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12861027"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12861027"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "J B Wilson, K Yamamoto, A S Marriott, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1211034"}], "href": "https://doi.org/10.1038/sj.onc.1211034"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18212739"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18212739"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Anaid Benitez, Wenjun Liu, Anna Palovcak, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FANCA Promotes DNA Double-Strand Break Repair by Catalyzing Single-Strand Annealing and Strand Exchange."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2018.06.030"}], "href": "https://doi.org/10.1016/j.molcel.2018.06.030"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30057198"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30057198"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Yan Li, Shi Chen, Jin Yuan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mesenchymal stem/progenitor cells promote the reconstitution of exogenous hematopoietic stem cells in Fancg-/- mice in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2008-07-168138"}], "href": "https://doi.org/10.1182/blood-2008-07-168138"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19129541"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19129541"}]}]}]}
Synonyms	XRCC9, FAG
Proteins	FANCG_HUMAN
NCBI Gene ID	2189
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

FANCG has 6,991 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 133 datasets.

Click the + buttons to view associations for FANCG from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

FANCG Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of FANCG gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of FANCG gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of FANCG gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of FANCG gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of FANCG gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of FANCG gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving FANCG protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of FANCG gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of FANCG gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of FANCG gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of FANCG gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of FANCG gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of FANCG gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with FANCG gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with FANCG gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of FANCG gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of FANCG gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of FANCG gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with FANCG gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with FANCG gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing FANCG protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of FANCG gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing FANCG protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing FANCG protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing FANCG protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with FANCG protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with FANCG protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing FANCG protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of FANCG gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with FANCG gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with FANCG gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with FANCG gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of FANCG protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by FANCG gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving FANCG gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving FANCG gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with FANCG gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with FANCG gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with FANCG gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with FANCG gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.