| HGNC Family | F-boxes (FBX) |
| Name | F-box protein 47 |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n FBXO47 is emerging as a multifunctional F‐box protein with critical roles in germ cell development and cell cycle regulation. In mammals, FBXO47 is expressed specifically during meiotic prophase I, where it interacts with telomeric shelterin components (TRF1/TRF2) to stabilize telomere attachment and facilitate the formation and maintenance of the synaptonemal complex; disruption of FBXO47 destabilizes these interactions, leading to aberrant homologous synapsis and male infertility."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In parallel, studies in Caenorhabditis elegans have identified the FBXO47‐homolog prom‑1 as a regulator ensuring the timely progression through meiotic prophase I by promoting proper homolog recognition and double‐strand break repair"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", highlighting a conserved role in meiosis. In addition to its function in meiotic chromosomal dynamics, FBXO47 is positioned within germline sex determination pathways. In medaka and orange‐spotted grouper, for example, FBXO47 acts downstream of the transcription factor FOXL3 and is upregulated in testicular tissue in response to androgen signals, indicating its importance in testis development."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Outside of reproduction, FBXO47 may also act as a tumor suppressor. Its preferential expression in normal kidney, liver, and pancreatic tissues—and its downregulation in corresponding tumors—suggest that it could inhibit tumorigenesis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ", and its modulation by small tRNA‐derived fragments in gastric cancer further underscores a role in controlling malignant cell behavior."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Finally, as a component of the SCF ubiquitin E3 ligase complex via interaction with SKP1, FBXO47 targets meiotic regulators such as HORMAD1 for proteasome‐mediated degradation, thereby modulating double‐strand break formation during early meiotic events."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Collectively, these findings delineate FBXO47 as a pivotal regulator of chromosomal dynamics during meiosis with additional implications in germ cell sex determination and tumor suppression.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Rong Hua, Huafang Wei, Chao Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FBXO47 regulates telomere-inner nuclear envelope integration by stabilizing TRF2 during meiosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkz992"}], "href": "https://doi.org/10.1093/nar/gkz992"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31724724"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31724724"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Nobuhiro Tanno, Kazumasa Takemoto, Yuki Takada-Horisawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FBXO47 is essential for preventing the synaptonemal complex from premature disassembly in mouse male meiosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "iScience (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.isci.2022.104008"}], "href": "https://doi.org/10.1016/j.isci.2022.104008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35310947"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35310947"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Verena Jantsch, Lois Tang, Pawel Pasierbek, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Caenorhabditis elegans prom-1 is required for meiotic prophase progression and homologous chromosome pairing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e07-03-0243"}], "href": "https://doi.org/10.1091/mbc.e07-03-0243"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17914060"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17914060"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Mariko Kikuchi, Toshiya Nishimura, Daisuke Saito, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel components of germline sex determination acting downstream of foxl3 in medaka."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Biol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ydbio.2018.10.019"}], "href": "https://doi.org/10.1016/j.ydbio.2018.10.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30392839"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30392839"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Fangmei Lin, Feng Tong, Qi He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "In vitro effects of androgen on testicular development by the AR-foxl3-rec8/fbxo47 axis in orange-spotted grouper (Epinephelus coioides)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gen Comp Endocrinol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ygcen.2020.113435"}], "href": "https://doi.org/10.1016/j.ygcen.2020.113435"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32057909"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32057909"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Barbara Simon-Kayser, Catherine Scoul, Karine Renaudin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular cloning and characterization of FBXO47, a novel gene containing an F-box domain, located in the 17q12 band deleted in papillary renal cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Chromosomes Cancer (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/gcc.20170"}], "href": "https://doi.org/10.1002/gcc.20170"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15723337"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15723337"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Fei Zhang, Jinxin Shi, Zhonghua Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A 3'-tRNA-derived fragment enhances cell proliferation, migration and invasion in gastric cancer by targeting FBXO47."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Biochem Biophys (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.abb.2020.108467"}], "href": "https://doi.org/10.1016/j.abb.2020.108467"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32592804"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32592804"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Yongjuan Guan, Huijuan Lin, N Adrian Leu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SCF ubiquitin E3 ligase regulates DNA double-strand breaks in early meiotic recombination."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkac304"}], "href": "https://doi.org/10.1093/nar/gkac304"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35489071"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35489071"}]}]}]}
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| Proteins | FBX47_HUMAN |
| NCBI Gene ID | 494188 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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FBXO47 has 2,009 functional associations with biological entities spanning 7 categories (molecular profile, functional term, phrase or reference, disease, phenotype or trait, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 53 datasets.
Click the + buttons to view associations for FBXO47 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of FBXO47 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of FBXO47 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of FBXO47 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of FBXO47 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CellMarker Gene-Cell Type Associations | cell types associated with FBXO47 gene from the CellMarker Gene-Cell Type Associations dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of FBXO47 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of FBXO47 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of FBXO47 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with FBXO47 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of FBXO47 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with FBXO47 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by FBXO47 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with FBXO47 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with FBXO47 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with FBXO47 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| DisGeNET Gene-Phenotype Associations | phenotypes associated with FBXO47 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at FBXO47 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of FBXO47 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of FBXO47 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing FBXO47 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with FBXO47 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of FBXO47 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of FBXO47 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of FBXO47 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of FBXO47 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GWAS Catalog SNP-Phenotype Associations | phenotypes associated with FBXO47 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations dataset. | |
| GWAS Catalog SNP-Phenotype Associations 2025 | phenotypes associated with FBXO47 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset. | |
| GWASdb SNP-Disease Associations | diseases associated with FBXO47 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
| GWASdb SNP-Phenotype Associations | phenotypes associated with FBXO47 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of FBXO47 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| HPA Tissue Protein Expression Profiles | tissues with high or low expression of FBXO47 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
| IMPC Knockout Mouse Phenotypes | phenotypes of mice caused by FBXO47 gene knockout from the IMPC Knockout Mouse Phenotypes dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for FBXO47 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of FBXO47 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of FBXO47 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of FBXO47 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of FBXO47 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles | cell lines with FBXO47 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain FBXO47 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by FBXO47 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of FBXO47 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| MPO Gene-Phenotype Associations | phenotypes of transgenic mice caused by FBXO47 gene mutations from the MPO Gene-Phenotype Associations dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of FBXO47 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of FBXO47 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at FBXO47 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of FBXO47 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of FBXO47 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of FBXO47 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of FBXO47 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of FBXO47 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with FBXO47 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with FBXO47 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
| WikiPathways Pathways 2024 | pathways involving FBXO47 protein from the WikiPathways Pathways 2024 dataset. | |
