FBXW10B Gene

Name F-box and WD repeat domain containing 10B
Description Members of the F-box protein family, such as FBXW10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n In the context of viral infection, an F‐box protein—specifically FBXW11—is a pivotal component of the SCF (SKP1–CUL1–F‐box) E3 ubiquitin ligase complex that targets key antiviral proteins for proteasomal degradation. For instance, during Rift Valley fever virus (RVFV) infection, the viral nonstructural protein NSs binds FBXW11 via a short degron sequence (DDGFVE) to assemble an active SCF complex. This complex recruits protein kinase R (PKR) and promotes its degradation, thereby blunting PKR’s antiviral action and facilitating efficient viral replication. Notably, under conditions that disrupt the formation or function of the SCF(FBXW11–NSs) complex—such as small molecule inhibition, mutagenesis of the NSs degron, or FBXW11 knockdown—PKR degradation is blocked, leading to PKR activation and subsequent suppression of RVFV infection. Overall, FBXW11 serves as a master regulator in this pathway by dictating the assembly of the SCF complex and thereby controlling the turnover of PKR, a finding that both deepens our mechanistic understanding of viral immune evasion and highlights potential therapeutic avenues."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Rajini Mudhasani, Julie P Tran, Cary Retterer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Protein Kinase R Degradation Is Essential for Rift Valley Fever Virus Infection and Is Regulated by SKP1-CUL1-F-box (SCF)FBXW11-NSs E3 Ligase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Pathog (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.ppat.1005437"}], "href": "https://doi.org/10.1371/journal.ppat.1005437"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26837067"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26837067"}]}]}]}
NCBI Gene ID 374286
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Download Associations
Predicted Functions View FBXW10B's ARCHS4 Predicted Functions.
Co-expressed Genes View FBXW10B's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View FBXW10B's ARCHS4 Predicted Functions.

Functional Associations

FBXW10B has 997 functional associations with biological entities spanning 6 categories (chemical, functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 16 datasets.

Click the + buttons to view associations for FBXW10B from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles tissue samples with high or low expression of FBXW10B gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
Carcinogenome Chemical Perturbation Carcinogenicity Signatures small molecule perturbations changing expression of FBXW10B gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
CM4AI KOLF21J CRISPRi Gene Perturbation Atlas gene perturbations changing expression of FBXW10B gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 cellular components containing FBXW10B protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 cellular components co-occuring with FBXW10B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
GTEx eQTL 2025 SNPs regulating expression of FBXW10B gene from the GTEx eQTL 2025 dataset.
GTEx Tissue Gene Expression Profiles 2023 tissues with high or low expression of FBXW10B gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
IMPC Knockout Mouse Phenotypes phenotypes of mice caused by FBXW10B gene knockout from the IMPC Knockout Mouse Phenotypes dataset.
JASPAR Predicted Human Transcription Factor Targets 2025 transcription factors regulating expression of FBXW10B gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.
LINCS L1000 CMAP Chemical Perturbation Consensus Signatures small molecule perturbations changing expression of FBXW10B gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset.
Rummagene Transcription Factor Associations 2026 transcription factors regulating expression of FBXW10B gene from the Rummagene Transcription Factor Associations 2026 dataset.
RummaGEO Drug Perturbation Signatures drug perturbations changing expression of FBXW10B gene from the RummaGEO Drug Perturbation Signatures dataset.
RummaGEO Gene Perturbation Signatures gene perturbations changing expression of FBXW10B gene from the RummaGEO Gene Perturbation Signatures dataset.
Tahoe Therapeutics Tahoe 100M Perturbation Atlas drug perturbations changing expression of FBXW10B gene from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 tissues with high expression of FBXW10B protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 tissues co-occuring with FBXW10B protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.