{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nA large genome‐wide association study of breast cancer identified a pericentromeric single nucleotide polymorphism on chromosome 1p11.2 residing within a broad linkage disequilibrium block adjacent to NOTCH2 and FCGR1B. The association signal was particularly strong for estrogen-receptor–positive tumors, suggesting that genetic variation in or near FCGR1B may play a role in breast cancer susceptibility through mechanisms that remain to be fully elucidated."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nOther investigations focusing on the broader family of high-affinity Fc gamma receptors have highlighted their importance in immune regulation across a number of disease contexts. For example, studies examining disease activity in conditions such as multiple sclerosis during pregnancy, adult-onset Still disease via monocyte CD64 expression, and alopecia areata through the detection of anti-Fcγ receptor I antibodies underscore that dysregulation of Fc receptor-mediated pathways is implicated in modulating inflammatory and autoimmune responses."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "2", "end_ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn a distinct clinical application, heightened FCGR1B mRNA expression in peripheral blood mononuclear cells has been shown to distinguish patients with active tuberculosis from those with latent infection, cured tuberculosis, pneumonia, or healthy status. The transcript level of FCGR1B correlated with bacterial load and C-reactive protein values, and its robust diagnostic performance (with high sensitivity and specificity) positions it as a promising molecular biomarker for active tuberculosis, including both pulmonary and extra-pulmonary forms."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Gilles Thomas, Kevin B Jacobs, Peter Kraft, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.353"}], "href": "https://doi.org/10.1038/ng.353"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19330030"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19330030"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Rinze F Neuteboom, Evert Verbraak, Annet F Wierenga-Wolf, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The monocyte transcriptome during pregnancy in multiple sclerosis: prominent expression of the Fc-receptor CD64."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mult Scler (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1352458510389628"}], "href": "https://doi.org/10.1177/1352458510389628"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21135020"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21135020"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Takashi Shimizu, Akie Kikuchi-Taura, Soichiro Tsuji, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Up-regulation of CD64 Expression on Monocytes in Patients With Active Adult-Onset Still Disease: A Possible Biomarker of Disease Activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Rheumatol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/RHU.0000000000000931"}], "href": "https://doi.org/10.1097/RHU.0000000000000931"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32073518"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32073518"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yoshihiro Kuwano, Manabu Fujimoto, Rei Watanabe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Serum anti-Fcgamma receptor autoantibodies in patients with alopecia areata."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Dermatol Res (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00403-006-0717-6"}], "href": "https://doi.org/10.1007/s00403-006-0717-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17124586"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17124586"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Y H Liu, R Wang, H J An, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Diagnostic value of "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "FCGR1B"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " gene transcription level in active tuberculosis]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhonghua Jie He He Hu Xi Za Zhi (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3760/cma.j.cn112147-20211213-00878"}], "href": "https://doi.org/10.3760/cma.j.cn112147-20211213-00878"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35381635"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35381635"}]}]}]}