{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent epigenetic analyses of cutaneous warts induced by human papillomavirus (HPV) infection have identified widespread alterations in DNA methylation patterns when compared to normal skin tissue."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Within this framework, the long non‐coding RNA FER1L6‑AS1 has emerged as a potential epigenetic regulator. Although the primary focus of the study was to delineate differences in methylation among a broad set of genes, preliminary observations suggest that FER1L6‑AS1 may undergo differential methylation in wart tissue relative to normal skin. This epigenetic modification hints at a functional role whereby FER1L6‑AS1 could modulate gene expression and impact cellular pathways relevant to HPV-induced lesion formation. Further detailed functional investigations are required to elucidate the precise molecular mechanisms and contributions of FER1L6‑AS1 in the development and progression of cutaneous warts.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Laith N Al-Eitan, Mansour A Alghamdi, Amneh H Tarkhan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-Wide Tiling Array Analysis of HPV-Induced Warts Reveals Aberrant Methylation of Protein-Coding and Non-Coding Regions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes (Basel) (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/genes11010034"}], "href": "https://doi.org/10.3390/genes11010034"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31892232"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31892232"}]}]}]}