FEZ2 Gene

Name	fasciculation and elongation protein zeta 2 (zygin II)
Description	This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Other orthologs include the rat gene that encodes zygin II, which can bind to synaptotagmin. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n FEZ2 is a multifunctional adapter protein that belongs to the FEZ family, sharing homology with FEZ1 yet exhibiting distinct expression dynamics and interaction profiles. Unlike FEZ1, which is predominantly expressed in neural tissue and is well known for its role in axonal transport and neuronal development, FEZ2 is more broadly expressed during embryonic development and in various adult tissues. Notably, FEZ2 has been shown to interact with protein kinase C ζ (PKCζ) to promote neurite extension in cellular models, suggesting a role in morphological remodeling in both neuronal and non‐neuronal cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, its documented interaction with NEK1—a kinase involved in DNA repair mechanisms and polycystic kidney disease—implies that FEZ2 may serve auxiliary functions in cell cycle regulation and genomic stability."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Further expanding its functional repertoire, FEZ2 has been found to reciprocally regulate autophagy in concert with RAB3GAP complexes, thus linking it to proteostasis and vesicular trafficking."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, genome‐wide expression analyses have highlighted FEZ2 as one of the genes significantly associated with age‐related transcriptional changes in skeletal muscle, positioning it among factors that may influence muscle aging processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Finally, recent studies in pancreatic ductal adenocarcinoma demonstrate that upregulation of FEZ2—often accompanied by hypomethylation of its gene—correlates with enhanced tumor cell proliferation, migration, and chemoresistance, thereby conferring an oncogenic role and poor clinical prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Collectively, these findings suggest that FEZ2 not only complements FEZ1 function in neuronal differentiation and transport but may also acquire novel additional roles in autophagy regulation, muscle aging, and tumorigenesis, underscoring its potential importance in both physiological and pathological contexts."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}, {"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Toshitsugu Fujita, Junko Ikuta, Juri Hamada, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2003.12.006"}], "href": "https://doi.org/10.1016/j.bbrc.2003.12.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14697253"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14697253"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Eliana M Assmann, Marcos R Alborghetti, Maria E R Camargo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M513280200"}], "href": "https://doi.org/10.1074/jbc.M513280200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16484223"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16484223"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Natalie Spang, Anne Feldmann, Heike Huesmann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RAB3GAP1 and RAB3GAP2 modulate basal and rapamycin-induced autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Autophagy (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/15548627.2014.994359"}], "href": "https://doi.org/10.4161/15548627.2014.994359"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25495476"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25495476"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Ingmar S Middelbos, Brittany M Vester, Lisa K Karr-Lilienthal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Age and diet affect gene expression profile in canine skeletal muscle."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0004481"}], "href": "https://doi.org/10.1371/journal.pone.0004481"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19221602"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19221602"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Chaozhi Yang, Xuebing Wang, Chenjie Qiu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "FEZ2"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " as a potential oncogene in pancreatic ductal adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PeerJ (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7717/peerj.12736"}], "href": "https://doi.org/10.7717/peerj.12736"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35036176"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35036176"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Marcos R Alborghetti, Ariane S Furlan, Jörg Kobarg "}, {"type": "b", "children": [{"type": "t", "text": "FEZ2 has acquired additional protein interaction partners relative to FEZ1: functional and evolutionary implications."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0017426"}], "href": "https://doi.org/10.1371/journal.pone.0017426"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21408165"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21408165"}]}]}]}
Synonyms	HUM3CL
Proteins	FEZ2_HUMAN
NCBI Gene ID	9637
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

FEZ2 has 6,280 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 111 datasets.

Click the + buttons to view associations for FEZ2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

FEZ2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of FEZ2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of FEZ2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of FEZ2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of FEZ2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of FEZ2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of FEZ2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of FEZ2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of FEZ2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of FEZ2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of FEZ2 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of FEZ2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of FEZ2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with FEZ2 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with FEZ2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of FEZ2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of FEZ2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of FEZ2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of FEZ2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing FEZ2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing FEZ2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing FEZ2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with FEZ2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with FEZ2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of FEZ2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with FEZ2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with FEZ2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with FEZ2 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of FEZ2 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by FEZ2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with FEZ2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with FEZ2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with FEZ2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with FEZ2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with FEZ2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at FEZ2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of FEZ2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of FEZ2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing FEZ2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with FEZ2 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with FEZ2 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.